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Review
. 2024 Jan 26;16(1):e53008.
doi: 10.7759/cureus.53008. eCollection 2024 Jan.

Spina Bifida Prevention: A Narrative Review of Folic Acid Supplements for Childbearing Age Women

Lloyd F Ledet Iii  1 , Connor J Plaisance  1 , Charles P Daniel  1 , Maxwell J Wagner  1 , Ivan Alvarez  1 , Caroline R Burroughs  1 , Ross Rieger  2 , Harish Siddaiah  2 , Shahab Ahmadzadeh  2 , Sahar Shekoohi  2 , Alan D Kaye  2 , Giustino Varrassi  3
Affiliations
Review

Spina Bifida Prevention: A Narrative Review of Folic Acid Supplements for Childbearing Age Women

Lloyd F Ledet Iii et al. Cureus. .

Abstract

Neural tube defects (NTDs) are malformations that occur during embryonic development, and they account for most central nervous system birth anomalies. Genetic and environmental factors have been shown to play a role in the etiology of NTDs. The different types of NTDs are classified according to anatomic location and severity of the defect, with most of the neural axis anomalies occurring in the caudal spinal or cranial areas. Spina bifida is a type of NTD that is characterized by an opening in the vertebral arch, and the level of severity is determined by the extent to which the neural tissue protrudes through the opened arch(es). Prevention of NTDs by administration of folic acid has been studied and described in the literature, yet there are approximately 300,000 cases of NTDs that occur annually, with 88,000 deaths occurring per year worldwide. A daily intake of at least 400 μg of folic acid is recommended especially for women of childbearing age. To provide the benefits of folic acid, prenatal vitamins are recommended in pregnancy, and many countries have been fortifying foods such as cereal grain products with folic acid; however, not all countries have instituted folic acid fortification programs. The present investigation includes a description of the pharmacology of folic acid, neural tube formation, defects such as spina bifida, and the relevance of folic acid to developing spina bifida. Women's knowledge and awareness of folic acid regarding its importance in the prevention of spina bifida is a major factor in reducing incidence worldwide.

Keywords: folate; folic acid; neural tube defects; neural tube development; spina bifida.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Metabolism of Folic Acid to L-5-Methyltetrahydrofolate After Intestinal Absorption.
See this image and copyright information in PMC

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