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Review
. 2024 Feb 9:12:1342906.
doi: 10.3389/fped.2024.1342906. eCollection 2024.

Acellular dermal matrix in urethral reconstruction

Jiang Aodi  1 , Lian Ying  1 , Sun Chengyang  1 , Zhai Hongfeng  1
Affiliations
Review

Acellular dermal matrix in urethral reconstruction

Jiang Aodi et al. Front Pediatr. .

Abstract

The management of severe urethral stricture has always posed a formidable challenge. Traditional approaches such as skin flaps, mucosal grafts, and urethroplasty may not be suitable for lengthy and intricate strictures. In the past two decades, tissue engineering solutions utilizing acellular dermal matrix have emerged as potential alternatives. Acellular dermal matrix (ADM) is a non-immunogenic biological collagen scaffold that has demonstrated its ability to induce layer-by-layer tissue regeneration. The application of ADM in urethral reconstruction through tissue engineering has become a practical endeavor. This article provides an overview of the preparation, characteristics, advantages, and disadvantages of ADM along with its utilization in urethral reconstruction via tissue engineering.

Keywords: acellular dermal matrix; hypospadias; regeneration; tissue engineering; urethral strictures.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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References

    1. Sam P, Jiang J, Leslie SW, LaGrange CA. Anatomy, abdomen and pelvis, sphincter urethrae. StatPearls [Internet]. Treasure Island, FL: StatPearls Publishing; (2024). PMID: - PubMed
    1. Krughoff K, Shapiro J, Peterson AC. Pelvic fracture urethral distraction defect. Urol Clin North Am. (2022) 49(3):383–91. 10.1016/j.ucl.2022.04.003 - DOI - PubMed
    1. Leslie SW, Nelson Q, Baker J. Urethral injury. StatPearls [Internet]. Treasure Island, FL: StatPearls Publishing; (2024). PMID: - PubMed
    1. Flynn H, Ong M, De Win G, Desai D. Narrowing in on urethral strictures. Aust J Gen Pract. (2021) 50(4):214–8. 10.31128/AJGP-03-20-5280 - DOI - PubMed
    1. Steenkamp JW, Heyns CF, de Kock ML. Internal urethrotomy versus dilation as treatment for male urethral strictures: a prospective, randomized comparison. J Urol. (1997) 157(1):98–101. 10.1016/S0022-5347(01)65296-0 - DOI - PubMed

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The author(s) declare that no financial support was received for the research, authorship, and/or publication of this article.