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Review
. 2024 Jan 30;10(2):115.
doi: 10.3390/jof10020115.

The Roles of Septins in Regulating Fission Yeast Cytokinesis

Shengnan Zheng  1   2 , Biyu Zheng  1   2 , Chuanhai Fu  1   2
Affiliations
Review

The Roles of Septins in Regulating Fission Yeast Cytokinesis

Shengnan Zheng et al. J Fungi (Basel). .

Abstract

Cytokinesis is required to separate two daughter cells at the end of mitosis, and septins play crucial roles in many aspects of cytokinesis. While septins have been intensively studied in many model organisms, including the budding yeast Saccharomyces cerevisiae, septins have been relatively less characterized in the fission yeast Schizosaccharomyces pombe, which has proven to be an excellent model organism for studying fundamental cell biology. In this review, we summarize the findings of septins made in fission yeasts mainly from four aspects: the domain structure of septins, the localization of septins during the cell cycle, the roles of septins in regulating cytokinesis, and the regulatory proteins of septins.

Keywords: Schizosaccharomyces pombe; cytokinesis; septin.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Domains and predicted structures of fission yeast septins. The fission yeast Schizosaccharomyces pombe has seven septins, namely Spn1–7. Spn1–4 function in vegetative cells, while Spn2, 5, 6, and 7 form a complex during meiosis to promote the formation of the forespore membrane. The domain structures were drawn according to the annotations in Pombase (www.pombase.org, accessed on 27 November 2023), and structures were predicted by AlphaFold (alphafold.ebi.ac.uk, accessed on 19 November 2023). The indicated domains are colored, and the N-terminal polybasic regions are indicated by arrows (basic residues are shown).
Figure 2
Figure 2
Schematic diagrams illustrating septin localization during the cell cycle. The localization of septins during the cell cycle in mammals (A), the budding yeast Saccharomyces cerevisiae (B), and the fission yeast Schizosaccharomyces pombe (C). Note that not all fission yeast septins localize to the lateral cortex during interphase. Graphs were generated with BioRender.com (accessed on 15 December 2023).
Figure 3
Figure 3
The roles of septins in regulating cytokinesis in fission yeast. (A) Before septin ring assembly, septins form puncta structures on the cell cortex and function as barriers to prevent premature accumulation of cortical proteins, including contractile actomyosin ring (CAR) components, Sid2, and glucan synthases, to the equatorial region. (B) When the CAR constricts, septin rings are assembled at the equatorial region, which is coordinated by the anillin-like protein Mid2. Septin double rings confine Sid2 and glucan synthases to the cleavage furrow to promote CAR constriction. In addition, septin double rings promote the proper localization of glucanases to the septum, where the primary septum is digested. Graphs were generated with BioRender.com (accessed on 15 December 2023).
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