Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1985;109(3):257-9.
doi: 10.1007/BF00390366.

Activity of a novel carotenoid analog, 4,4'-(3,7,12,16-tetramethyl-1,3,5,7,9,11,13,15,17-octadecanonaen -1,18- diyl) bis(1-ethylpyridinium) dibromide (Y-18598) on mouse leukemia P388

T Okumoto, N Morita, I Nakamura, M Konishi, M Yamaguchi

Activity of a novel carotenoid analog, 4,4'-(3,7,12,16-tetramethyl-1,3,5,7,9,11,13,15,17-octadecanonaen -1,18- diyl) bis(1-ethylpyridinium) dibromide (Y-18598) on mouse leukemia P388

T Okumoto et al. J Cancer Res Clin Oncol. 1985.

Abstract

4,4'-(3,7,12,16-Tetramethyl-1,3,5,7,9,11,13,15,17-octadecanonaen-1 ,18-diyl) bis (1-ethylpyridinium) dibromide (Y-18598), a novel carotenoid analog with 1-ethylpyridine rings as terminal groups, was found to be effective against P388 leukemia which was refractory to amphotericin B and retinoic acid used as representatives of polyene-containing drugs. The life span of leukemic mice was increased by 56% over the control following administration of 2.5 mg/kg on days 1-5. Among these polyene-containing compounds, Y-18598 was the most highly cytotoxic to P388 leukemia cells in vitro.

PubMed Disclaimer

Similar articles

See all similar articles

References

    1. Cell. 1978 Oct;15(2):393-403 - PubMed
    1. Proc Natl Acad Sci U S A. 1978 Sep;75(9):4349-53 - PubMed
    1. Biomedicine. 1979 Sep;31(5):122-3 - PubMed
    1. Cancer Res. 1976 Nov;36(11 Pt 1):4069-73 - PubMed
    1. J Natl Cancer Inst. 1975 Jun;54(6):1489-91 - PubMed

LinkOut - more resources