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. 2024 Dec;56(1):2315225.
doi: 10.1080/07853890.2024.2315225. Epub 2024 Feb 9.

Association between neutrophil to high-density lipoprotein cholesterol ratio and disease severity in patients with acute biliary pancreatitis

Lin Yang  1 , Chiyi He  1 , Wei Wang  1
Affiliations

Association between neutrophil to high-density lipoprotein cholesterol ratio and disease severity in patients with acute biliary pancreatitis

Lin Yang et al. Ann Med. 2024 Dec.

Abstract

Background: The neutrophil to high-density lipoprotein cholesterol ratio (NHR) is independently associated with the severity of various diseases. However, its association with acute biliary pancreatitis (ABP) remains unknown.

Methods: This study included 1335 eligible patients diagnosed with ABP from April 2016 to December 2022. Patients were divided into low- and high-NHR level groups using an optimal cut-off value determined utilizing Youden's index. Multivariate logistic regression analysis was used to investigate the correlation between NHR and ABP severity. Multivariate analysis-based limited restricted cubic spline (RCS) method was used to evaluate the nonlinear relationship between NHR and the risk of developing moderate or severe ABP.

Results: In this study, multivariate logistic regression analysis indicated an independent association between NHR and ABP severity (p < .001). The RCS analysis showed a linear correlation between NHR and the risk of developing moderate or severe ABP (P for non-linearity > 0.05), and increased NHR was found to be independently associated with a more severe form of the disease.

Conclusions: Our study suggests that NHR is a simple and practical independent indicator of disease severity, serving as a potential novel predictor for patients with ABP.

Keywords: Acute biliary pancreatitis; disease severity; neutrophil to high-density lipoprotein cholesterol ratio.

Plain language summary

This study is the first to report on the independent association between the neutrophil to high-density lipoprotein cholesterol ratio (NHR) and acute biliary pancreatitis (ABP) severity.The restricted cubic spline analysis showed a linear correlation between NHR and the risk of developing moderate or severe ABP.Increased NHR levels are independently associated with a more severe degree of the disease.

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Conflict of interest statement

The authors report no conflict of interest.

Figures

Figure 1.
Figure 1.
Flow chart of the patient selection process.
Figure 2.
Figure 2.
Receiver operating curve of the NHR for prediction of disease severity in patients with acute biliary pancreatitis.
Figure 3.
Figure 3.
Associations of the NHR and the risk of developing moderate or severe acute biliary pancreatitis using restricted cubic spline.
See this image and copyright information in PMC

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