Virus-like particles (VLPs): A promising platform for combating against Newcastle disease virus
- PMID: 38283623
- PMCID: PMC10811427
- DOI: 10.1016/j.jvacx.2024.100440
Virus-like particles (VLPs): A promising platform for combating against Newcastle disease virus
Abstract
The global poultry industry plays a pivotal role in providing eggs and meat for human consumption. However, outbreaks of viral disease, especially Newcastle virus disease (NDV), within poultry farms have detrimental effects on various zootechnical parameters, such as body weight gain, feed intake, feed conversion ratio, as well as the quality of egg and meat production. Cases of vaccine failure have been reported in regions where highly pathogenic strains of NDV are prevalent. To tackle this challenge, virus-like particles (VLPs) have emerged as a potential solution. VLPs closely resemble natural viruses, offering biocompatibility and immune-stimulating properties that make them highly promising for therapeutic applications against NDV. Hence, this review emphasizes the significance of NDV and the need for effective treatments. The manuscript will contain several key aspects, starting with an exploration of the structure and properties of NDV. Subsequently, the paper will delve into the characteristics and benefits of VLPs compared to conventional drug delivery systems. A comprehensive analysis of VLPs as potential vaccine candidates targeting NDV will be presented, along with a discussion on strategies for loading cargo into these NDV-targeting VLPs. The review will also examine various expression systems utilized in the production of NDV-targeting VLPs. Additionally, the manuscript will address future prospects and challenges in the field, concluding with recommendations for further research.
Keywords: Cargo delivery; Delivery vehicles; Expression systems; Newcastle virus disease; VLPs; Vaccine.
© 2024 Published by Elsevier Ltd.
Conflict of interest statement
The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Ali niazi reports was provided by Shiraz University. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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References
-
- Alexander D.J., Aldous E.W., Fuller C.M. The long view: a selective review of 40 years of Newcastle disease research. Avian Pathol. 2012;41:329–335. - PubMed
-
- Dewidar A.A., El-Sawah A., Shany S.A., Dahshan A.-H.-M., Ali A. Genetic characterization of genotype VII. 1.1 Newcastle Disease viruses from commercial and backyard broiler chickens in Egypt. Ger. J Vet Res. 2021;1:11–17.
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