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Review
. 2024 Jan 10:11:1279384.
doi: 10.3389/fchem.2023.1279384. eCollection 2023.

Research progress of plant-derived natural products in thyroid carcinoma

Qiujing Du  1   2 , Weidong Shen  1
Affiliations
Review

Research progress of plant-derived natural products in thyroid carcinoma

Qiujing Du et al. Front Chem. .

Abstract

Thyroid carcinoma (TC) is a prevalent malignancy of the endocrine system, with a notable rise in its detection rate in recent decades. The primary therapeutic approaches for TC now encompass thyroidectomy and radioactive iodine therapy, yielding favorable prognoses for the majority of patients. TC survivors may necessitate ongoing surveillance, remedial treatment, and thyroid hormone supplementation, while also enduring the adverse consequences of thyroid hormone fluctuations, surgical complications, or side effects linked to radioactive iodine administration, and encountering enduring physical, psychosocial, and economic hardships. In vitro and in vivo studies of natural products against TC are demonstrating the potential of these natural products as alternatives to the treatment of thyroid cancer. This therapy may offer greater convenience, affordability, and acceptability than traditional therapies. In the early screening of natural products, we mainly use a combination of database prediction and literature search. The pharmacological effects on TC of selected natural products (quercetin, genistein, apigenin, luteolin, chrysin, myricetin, resveratrol, curcumin and nobiletin), which hold promise for therapeutic applications in TC, are reviewed in detail in this article through most of the cell-level evidence, animal-level evidence, and a small amount of human-level evidence. In addition, this article explores possible issues, such as bioavailability, drug safety.

Keywords: drug resistance; natural product; redifferentiation; thyroid carcinoma; thyroid carcinoma survivors; treatment challenges.

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Conflict of interest statement

The author declares that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

None
The pharmacological effects on TC of selected natural products (quercetin, genistein, apigenin, luteolin, chrysin, myricetin, resveratrol, curcumin and nobiletin), which hold promise for therapeutic applications in TC, are reviewed in detail in this article through most of the cell-level evidence, animal-level evidence, and a small amount of human-level evidence. All plant images, including herbs, are from Wikipedia. This image is drawn by Figdraw, and the image number for which the copyright is granted is OSTTP7c868.
See this image and copyright information in PMC

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Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. The Wuxi “Taihu Talent Plan” Excellent Medical Expert Team Project is supporting the research, authorship, and publication of this article as a funding source.

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