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Review
. 2024 Jan 22;14(5):3359-3378.
doi: 10.1039/d3ra07075a. eCollection 2024 Jan 17.

Functional electrospun nanofibers: fabrication, properties, and applications in wound-healing process

Qianlan Zheng  1 , Yuewei Xi  1   2 , Yunxuan Weng  1   2
Affiliations
Review

Functional electrospun nanofibers: fabrication, properties, and applications in wound-healing process

Qianlan Zheng et al. RSC Adv. .

Abstract

Electrostatic spinning as a technique for producing nanoscale fibers has recently attracted increasing attention due to its simplicity, versatility, and loadability. Nanofibers prepared by electrostatic spinning have been widely studied, especially in biomedical applications, because of their high specific surface area, high porosity, easy size control, and easy surface functionalization. Wound healing is a highly complex and dynamic process that is a crucial step in the body's healing process to recover from tissue injury or other forms of damage. Single-component nanofibers are more or less limited in terms of structural properties and do not fully satisfy various needs of the materials. This review aims to provide an in-depth analysis of the literature on the use of electrostatically spun nanofibers to promote wound healing, to overview the infinite possibilities for researchers to tap into their biomedical applications through functional composite modification of nanofibers for advanced and multifunctional materials, and to propose directions and perspectives for future research.

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Conflict of interest statement

There are no conflicts to declare.

Figures

Fig. 1
Fig. 1. Annual issues (2008–2022); search the science web for terms “electrospinning” and “wound healing”.
Fig. 2
Fig. 2. (a) Schematic of the appearance of the electrospinning machine (b) schematic of the electrospinning process.
Fig. 3
Fig. 3. (a) Dry electrospinning (b) wet electrospinning (c) coaxial electrospinning and (d) bubble electrospinning, illustrated from the literature.
Fig. 4
Fig. 4. (a) Needleless electrospinning (b) single-needle electrospinning (c) coaxial electrospinning and (d) multineedle electrospinning.
Fig. 5
Fig. 5. Four stages of wound healing: (a) hemostasis (b) inflammation (c) proliferation and (d) remodeling. The aforementioned references serve as the foundation for this information. The citation is derived from ref. .
Fig. 6
Fig. 6. Graphical abstract from the article titled “Electrospun ZnO-loaded chitosan/PCL bilayer membranes with spatially designed structure for accelerated wound healing” is paraphrased here.
Fig. 7
Fig. 7. Schematic of the controlled release of electrospinning drugs, from the literature.
Fig. 8
Fig. 8. Schematic of (a) sequential ES (b) synchronized ES (c) coaxial ES and (d) side-by-side ES.
See this image and copyright information in PMC

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