Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2024 Jan 3;46(1):469-484.
doi: 10.3390/cimb46010030.

Molecular Foundations of Inflammatory Diseases: Insights into Inflammation and Inflammasomes

Mi Eun Kim  1 , Jun Sik Lee  1
Affiliations
Review

Molecular Foundations of Inflammatory Diseases: Insights into Inflammation and Inflammasomes

Mi Eun Kim et al. Curr Issues Mol Biol. .

Abstract

Inflammatory diseases are a global health problem affecting millions of people with a wide range of conditions. These diseases, including inflammatory bowel disease (IBD), rheumatoid arthritis (RA), osteoarthritis (OA), gout, and diabetes, impose a significant burden on patients and healthcare systems. A complicated interaction between genetic variables, environmental stimuli, and dysregulated immune responses shows the complex biological foundation of various diseases. This review focuses on the molecular mechanisms underlying inflammatory diseases, including the function of inflammasomes and inflammation. We investigate the impact of environmental and genetic factors on the progression of inflammatory diseases, explore the connection between inflammation and inflammasome activation, and examine the incidence of various inflammatory diseases in relation to inflammasomes.

Keywords: inflammasome; inflammation; inflammatory diseases; signaling pathway.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflicts of interest.

Similar articles

See all similar articles

Cited by

References

    1. Falcon R.M.G., Caoili S.E.C. Immunologic, genetic, and ecological interplay of factors involved in allergic diseases. Front. Allergy. 2023;4:1215616. doi: 10.3389/falgy.2023.1215616. - DOI - PMC - PubMed
    1. Chen L., Deng H., Cui H., Fang J., Zuo Z., Deng J., Li Y., Wang X., Zhao L. Inflammatory responses and inflammation-associated diseases in organs. Oncotarget. 2018;9:7204–7218. doi: 10.18632/oncotarget.23208. - DOI - PMC - PubMed
    1. Touil H., Mounts K., De Jager P.L. Differential impact of environmental factors on systemic and localized autoimmunity. Front. Immunol. 2023;14:1147447. doi: 10.3389/fimmu.2023.1147447. - DOI - PMC - PubMed
    1. Marshall J.S., Warrington R., Watson W., Kim H.L. An introduction to immunology and immunopathology. Allergy Asthma Clin. Immunol. 2018;14((Suppl. 2)):49. doi: 10.1186/s13223-018-0278-1. - DOI - PMC - PubMed
    1. Amarante-Mendes G.P., Adjemian S., Branco L.M., Zanetti L.C., Weinlich R., Bortoluci K.R. Pattern Recognition Receptors and the Host Cell Death Molecular Machinery. Front. Immunol. 2018;9:2379. doi: 10.3389/fimmu.2018.02379. - DOI - PMC - PubMed

Grants and funding

LinkOut - more resources