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Review
. 2024 Jun;45(6):2445-2460.
doi: 10.1007/s10072-023-07292-9. Epub 2024 Jan 16.

Symptoms and age of prodromal Alzheimer's disease in Down syndrome: a systematic review and meta-analysis

Eri Shimizu  1 , Keiko Goto-Hirano  2 , Yumiko Motoi  3 , Masami Arai  1 , Nobutaka Hattori  4
Affiliations
Review

Symptoms and age of prodromal Alzheimer's disease in Down syndrome: a systematic review and meta-analysis

Eri Shimizu et al. Neurol Sci. 2024 Jun.

Abstract

The diagnostic criteria for adult-onset Alzheimer's disease (AD) in patients with Down syndrome (DS) have not been standardised. This study investigated the specific symptoms of AD in the prodromal stage of DS, the mean age at diagnosis at each stage of dementia, and the relationship between intellectual disability (ID) and dementia. PubMed, Web of Science, and Embase were searched for studies on DS, AD, early-stage disease, initial symptoms, and prodromal dementia registered between January 2012 and January 2022. We also performed a meta-analysis of the differences between the mean age at prodromal symptoms and AD diagnosis and the proportion of mild cognitive impairment in patients with mild and moderately abnormal ID. We selected 14 articles reporting the behavioural and psychological symptoms of dementia (BPSD) and memory- and language-related impairments as early symptoms of AD in patients with DS. The specific symptoms of BPSD were classified into five categories: irritability (agitation), apathy, abnormal behaviour, adaptive functioning, and sleep disturbance. The mean age at the diagnosis of prodromal symptoms and AD dementia was 52.7 and 56.2 years, respectively (mean difference, + 3.11 years; 95% CI 1.82-4.40) in the meta-analysis. The diagnosis of mild dementia tended to correlate with ID severity (odds ratio [OR], 1.38; 95% CI 0.87-2.18). The features of behaviour-variant frontotemporal dementia may be clinically confirmed in diagnosing early symptoms of DS-associated AD (DSAD). Moreover, age-appropriate cognitive assessment is important. Further studies are required to evaluate DSAD using a combination of biomarkers and ID-related data.

Keywords: Alzheimer’s disease; BPSD; Down syndrome; Prodromal symptoms.

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References

    1. Bayen E, Possin KL, Chen Y et al (2018) Prevalence of aging, dementia, and multimorbidity in older adults with Down syndrome. JAMA 1399–1406. https://doi.org/10.1001/jama.2018.2210
    1. Tsou AY, Bulova P, Capone G et al (2020) Medical care of adults with Down syndrome: a clinical guideline. JAMA 324:1543–1556. https://doi.org/10.1001/jama.2020.17024 - DOI - PubMed
    1. Fortea J, Zaman SH, Hartley S et al (2021) Alzheimer’s disease associated with Down syndrome: a genetic form of dementia. Lancet Neurol 20:930–942. https://doi.org/10.1016/S1474-4422(21)00245-3 - DOI - PubMed - PMC
    1. Ballard C, Mobley W, Hardy W et al (2016) Dementia in Down’s syndrome. Lancet Neurol 15:622–636. https://doi.org/10.1016/S1474-4422(16)00063-6 - DOI - PubMed
    1. Ponroy Bally B, Murai KK (2021) Astrocytes in Down syndrome across the lifespan. Front Cell Neurosci 15:702685. https://doi.org/10.3389/fncel.2021.702685 - DOI - PubMed - PMC

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