Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Jan 15;38(1):99-106.
doi: 10.7507/1002-1892.202309045.

[Research advances on stem cell-based treatments in animal studies and clinical trials of lymphedema]

[Article in Chinese]
Junzhe Chen  1 , Chengliang Deng  1   2
Affiliations

[Research advances on stem cell-based treatments in animal studies and clinical trials of lymphedema]

[Article in Chinese]
Junzhe Chen et al. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. .

Abstract
in English, Chinese

Objective: To summarize the progress of the roles and mechanisms of various types of stem cell-based treatments and their combination therapies in both animal studies and clinical trials of lymphedema.

Methods: The literature on stem cell-based treatments for lymphedema in recent years at home and abroad was extensively reviewed, and the animal studies and clinical trials on different types of stem cells for lymphedema were summarized.

Results: Various types of stem cells have shown certain effects in animal studies and clinical trials on the treatment of lymphedema, mainly through local differentiation into lymphoid endothelial cells and paracrine cytokines with different functions. Current research focuses on two cell types, adipose derived stem cells and bone marrow mesenchymal stem cells, both of which have their own advantages and disadvantages, mainly reflected in the therapeutic effect of stem cells, the difficulty of obtaining stem cells and the content in vivo. In addition, stem cells can also play a synergistic role in combination with other treatments, such as conservative treatment, surgical intervention, cytokines, biological scaffolds, and so on. However, it is still limited to the basic research stage, and only a small number of studies have completed clinical trials.

Conclusion: Stem cells have great transformation potential in the treatment of lymphedema, but there is no unified standard in the selection of cell types, the amount of transplanted cells, and the timing of transplantation.

目的: 综述不同类型干细胞及其联合疗法治疗淋巴水肿的基础和临床研究进展。.

方法: 广泛查阅国内外近年干细胞治疗淋巴水肿有关文献，对不同类型干细胞治疗淋巴水肿的动物实验和临床研究进行总结。.

结果: 动物实验和临床研究均显示各类干细胞治疗淋巴水肿有一定效果，主要通过局部分化为淋巴内皮细胞和旁分泌不同功能的细胞因子发挥作用。目前研究集中于脂肪来源干细胞和BMSCs两种细胞类型，两者各有优缺点，主要体现在干细胞治疗效果、获取难度和体内含量等方面。此外，干细胞还能联合其他治疗方式发挥协同作用，例如保守治疗、手术干预、细胞因子、生物支架等。但目前仍局限于基础研究阶段，仅少量研究完成了临床试验。.

结论: 干细胞治疗淋巴水肿具有较大临床转化潜力，但目前在细胞类型选择、移植细胞量、移植时机等方面尚缺乏统一标准。.

Keywords: Stem cells; lymphatic regeneration; lymphedema; regenerative medicine; tissue engineering.

PubMed Disclaimer

Similar articles

See all similar articles

References

    1. Brown S, Dayan JH, Kataru RP, et al The vicious circle of stasis, inflammation, and fibrosis in lymphedema. Plast Reconstr Surg. 2023;151(2):330e–341e. doi: 10.1097/PRS.0000000000009866. - DOI - PMC - PubMed
    1. Schulze H, Nacke M, Gutenbrunner C, et al Worldwide assessment of healthcare personnel dealing with lymphoedema. Health Econ Rev. 2018;8(1):10. doi: 10.1186/s13561-018-0194-6. - DOI - PMC - PubMed
    1. McLaughlin SA, Brunelle CL, Taghian A Breast cancer-related lymphedema: Risk factors, screening, management, and the impact of locoregional treatment. J Clin Oncol. 2020;38(20):2341–2350. doi: 10.1200/JCO.19.02896. - DOI - PMC - PubMed
    1. Ogino R, Yokooji T, Hayashida M, et al Emerging anti-inflammatory pharmacotherapy and cell-based therapy for lymphedema. Int J Mol Sci. 2022;23(14):7614. doi: 10.3390/ijms23147614. - DOI - PMC - PubMed
    1. Barufi S, Pereira de Godoy HJ, Pereira de Godoy JM, et al Exercising and compression mechanism in the treatment of lymphedema. Cureus. 2021;13(7):e16121. doi: 10.7759/cureus.16121. - DOI - PMC - PubMed

Publication types

Grants and funding

贵州省科技计划重点项目（ZK2021-011）；贵州省科技计划项目（［2021］079、［2020］1Y331）；中国教育部协同创新中心项目（2020-39）；遵义医科大学未来著名临床医生计划项目（rc220211202）

LinkOut - more resources