Comprehensive approach to controlling chronic hepatitis B in China
- PMID: 38176692
- PMCID: PMC11016498
- DOI: 10.3350/cmh.2023.0412
Comprehensive approach to controlling chronic hepatitis B in China
Abstract
Hepatitis B virus (HBV) infection was highly endemic in China, where the prevalence of HBsAg was 9.7% in 1992. Comprehensive strategies, including universal infant hepatitis B vaccination with emphasis on timely birth-dose and 3-dose coverage, dramatically reduced the mother-to-infant transmission and early childhood acquisition of HBV, resulting in estimated HBsAg prevalence rates of 5.6% and 0.1% in the general population and among children aged <5 years in 2022, respectively. Clinical guidelines on the prevention and treatment of chronic hepatitis B have been periodically updated based on emerging evidence from clinical research. The continuously improved reimbursement policy and the massively reduced price of antiviral drugs through government negotiation and central procurement have increased treatment accessibility and affordability. However, due to the low rates of diagnosis and treatment, China still faces a large challenge in achieving the 2030 goal of lowering HBV-related mortality by 65%. A public health approach involving concerted efforts from the government, medical community, industry, and society as a whole would be necessary to increase the uptake of HBV tests and treatment to achieve the global goal of eliminating viral hepatitis as a public health threat by 2030.
Keywords: China; Health insurance reimbursement; Hepatitis B; Prevention; Treatment.
Conflict of interest statement
The authors have no conflicts to disclose.
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References
-
- Iannacone M, Guidotti LG. Immunobiology and pathogenesis of hepatitis B virus infection. Nat Rev Immunol. 2022;22:19–32. - PubMed
-
- McMahon BJ. Natural history of chronic hepatitis B. Clin Liver Dis. 2010;14:381–396. - PubMed
-
- World Health Organization (WHO) Global progress report on HIV, viral hepatitis and sexually transmitted infections. 2021. WHO web site, < https://www.who.int/publications/i/item/9789240027077>. Accessed 31 Aug 2023.
-
- Chen S, Li J, Wang D, Fung H, Wong LY, Zhao L. The hepatitis B epidemic in China should receive more attention. Lancet. 2018;391:1572. - PubMed
-
- Polaris Observatory Collaborators Global prevalence, treatment, and prevention of hepatitis B virus infection in 2016: a modelling study. Lancet Gastroenterol Hepatol. 2018;3:383–403. - PubMed
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