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Review
. 2023 Dec;39(12):1146-1150.

[Research progress of the effect of "gut-immune" axis on bone homeostasis]

[Article in Chinese]
Jingyi Liu  1 , Wantao Dong  2 , Shiming Qiu  1 , Peng Yuan  1 , Pan Yang  1
Affiliations
  • PMID: 38140876
Review

[Research progress of the effect of "gut-immune" axis on bone homeostasis]

[Article in Chinese]
Jingyi Liu et al. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2023 Dec.

Abstract

Bone homeostasis is based on the dynamic balance of bone formation and bone resorption. An imbalance in bone homeostasis is a major contributor to many skeletal diseases, including osteoporosis. Changes in the composition and diversity of the gut microbiota (GM) are supposed to have a significant impact on bone homeostasis and are closely correlated with changes in bone mass and bone microarchitecture. The "gut-immune" axis, which is formed by the interaction between the host intestinal immune system and GM, is essential for maintaining bone homeostasis, as well as regulating the body's immunological response and maintaining immune homeostasis throughout the intestine and body. The article reviews recent advances in the study of GM, the immune system, and their synergistic impact on bone homeostasis.

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