Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2024 Feb;46(1):33-41.
doi: 10.1111/ijlh.14211. Epub 2023 Dec 17.

MicroRNA-based therapies: Revolutionizing the treatment of acute myeloid leukemia

Radhakrishnan Chandraprabha Vineetha  1 , John Anitha Geetha Raj  1 , Padmakumar Devipriya  1 , Mohanan Sreelatha Mahitha  1 , Sreedharan Hariharan  1
Affiliations
Review

MicroRNA-based therapies: Revolutionizing the treatment of acute myeloid leukemia

Radhakrishnan Chandraprabha Vineetha et al. Int J Lab Hematol. 2024 Feb.

Abstract

MicroRNAs (miRNAs) are small noncoding epigenetic regulators that exert critical significance by influencing target mRNAs and governing gene expression patterns and cellular signaling pathways. miRNAs play a pivotal role in a wide array of biological processes, including cell differentiation, proliferation, and survival. Numerous miRNAs contribute to tumorigenesis and cancer progression by promoting tumor growth, angiogenesis, invasion, and immune evasion, while others exert tumor suppressive effects. From a clinical perspective, it has been demonstrated that numerous miRNAs are related to the prognosis in acute myeloid leukemia (AML) patients. They hold the potential to be utilized as biomarkers, aiding in improved treatment decision-making. Moreover, a number of preclinical investigations have offered compelling evidence to create novel treatment approaches that target miRNAs in AML. This review highlights the clinical significance of miRNAs in the diagnosis, prognosis, and treatment response of adult patients with AML.

Keywords: acute myeloid leukemia; cancer; cytogenetics; microRNA; prognosis.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

REFERENCES

    1. Lu L, McCurdy S, Huang S, et al. Time series miRNA-mRNA integrated analysis reveals critical miRNAs and targets in macrophage polarization. Sci Rep. 2016;6(1):1-14. doi:10.1038/srep37446
    1. Lewis BP, Burge CB, Bartel DP. Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell. 2005;120(1):15-20. doi:10.1016/j.cell.2004.12.035
    1. Vitsios DM, Davis MP, van Dongen S, Enright AJ. Large-scale analysis of microRNA expression, epi-transcriptomic features and biogenesis. Nucleic Acids Res. 2017;45(3):1079-1090. doi:10.1093/nar/gkw1031
    1. Wang X, Chen H, Bai J, He A. MicroRNA: an important regulator in acute myeloid leukemia. Cell Biol Int. 2017;41(9):936-945. doi:10.1002/cbin.10770
    1. Arber DA, Orazi A, Hasserjian R, et al. The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia. Blood. 2016;127(20):2391-2405. doi:10.1182/blood-2016-03-643544

LinkOut - more resources