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Review
. 2023 Dec 11;10(4):382-387.
doi: 10.1055/s-0043-1777087. eCollection 2023 Dec.

Mesenchymal Stem Cells Applications in Alzheimer's Disease

Oluwatosin Debola Oyebode  1 , Pınar Tulay  1   2   3
Affiliations
Review

Mesenchymal Stem Cells Applications in Alzheimer's Disease

Oluwatosin Debola Oyebode et al. Glob Med Genet. .

Abstract

Alzheimer's disease (AD) is a neurodegenerative disorder that advances gradually and primarily impacts the hippocampus region of the brain. It is defined by a deterioration in cognitive function as well as an observable loss of memory retention. One of the major characteristics of AD is the impairment of neural generation, resulting in the depletion of neurons and synaptic connections within the nervous system. It is unfortunate to say that, at present, no definitive cure is available for AD, and no medication is effective in halting the progression of neurodegeneration associated with it. Nevertheless, it is crucial to highlight that progress has been achieved in addressing the troubling symptoms of AD. The Food and Drug Administration has granted approval for two categories of medications designed to alleviate these symptoms. The scientific community has been inspired by these advancements to investigate alternative therapeutic options, with an emphasis on stem cell therapy in particular. The main focus of this review will be on the potential for the use of a variety of mesenchymal stem cells as a treatment for AD.

Keywords: Alzheimer's disease (AD); Aβ plaques; mesenchymal stem cells; microglia; neuroinflammation.

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Conflict of interest statement

Conflicts of Interest None declared.

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References

    1. Hu J, Wang X. Alzheimer's disease: from pathogenesis to mesenchymal stem cell therapy - bridging the missing link. Front Cell Neurosci. 2022;15:811852. - PMC - PubMed
    1. Duncan T, Valenzuela M. Alzheimer's disease, dementia, and stem cell therapy. Stem Cell Res Ther. 2017;8(01):111. - PMC - PubMed
    1. Lane C A, Hardy J, Schott J M. Alzheimer's disease. Eur J Neurol. 2018;25(01):59–70. - PubMed
    1. Khan S, Barve K H, Kumar M S. Recent advancements in pathogenesis, diagnostics and treatment of Alzheimer's disease. Curr Neuropharmacol. 2020;18(11):1106–1125. - PMC - PubMed
    1. Breijyeh Z, Karaman R. Comprehensive review on Alzheimer's disease: causes and treatment. Molecules. 2020;25(24):5789. - PMC - PubMed