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Review
. 2023 Nov 22:14:1303072.
doi: 10.3389/fimmu.2023.1303072. eCollection 2023.

The emerging role and therapeutic implications of bacterial and parasitic deubiquitinating enzymes

Markus Wehrmann  1   2 , David Vilchez  1   2   3   4
Affiliations
Review

The emerging role and therapeutic implications of bacterial and parasitic deubiquitinating enzymes

Markus Wehrmann et al. Front Immunol. .

Abstract

Deubiquitinating enzymes (DUBs) are emerging as key factors for the infection of human cells by pathogens such as bacteria and parasites. In this review, we discuss the most recent studies on the role of deubiquitinase activity in exploiting and manipulating ubiquitin (Ub)-dependent host processes during infection. The studies discussed here highlight the importance of DUB host-pathogen research and underscore the therapeutic potential of inhibiting pathogen-specific DUB activity to prevent infectious diseases.

Keywords: autophagy and apoptosis; deubiquitinating enzymes (DUBs); immune responses; infection mechanisms; ubiquitin.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Classification of different DUB mechanisms during bacterial and parasitic infections. (A) Maintenance of replication niche inside the host by clearance of ubiquitination on the vacuole membrane and hijacking of trafficking pathways. (B) Downregulation of the immune system response such as macrophages and NF-κB signalling due to infectious DUB activity. (C) Protection from degradation by removing K63-polyubiquitination signals that are responsible for regulating autophagy and apoptosis. (D) Hijacking and manipulation of host DUBs upon entrance and infection of the cell that are regulating cellular defence systems such as apoptosis and NF-κB signalling.
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References

    1. Nandi D, Tahiliani P, Kumar A, Chandu D. The ubiquitin-proteasome system. J Biosci (2006) 19:137–55. doi: 10.1007/BF02705243 - DOI - PubMed
    1. Liao Y, Sumara I, Pangou E. Non-proteolytic ubiquitylation in cellular signaling and human disease. Commun Biol (2022) 5:114. doi: 10.1038/s42003-022-03060-1 - DOI - PMC - PubMed
    1. Kelsall IR. Non-lysine ubiquitylation: Doing things differently. Front Mol Biosci (2022) 9:1008175. doi: 10.3389/fmolb.2022.1008175 - DOI - PMC - PubMed
    1. Yau R, Rape M. The increasing complexity of the ubiquitin code. Nat Cell Biol (2016) 18:579–86. doi: 10.1038/ncb3358 - DOI - PubMed
    1. Fiil BK, Gyrd-Hansen M. The Met1-linked ubiquitin machinery in inflammation and infection. Cell Death Differ (2021) 28:557–69. doi: 10.1038/s41418-020-00702-x - DOI - PMC - PubMed

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Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was supported by the Deutsche Forschungsgemeinschaft (DFG) (VI742/4-1 and Germany’s Excellence Strategy-CECAD, EXC 2030-390661388). MW received support by the Cologne Graduate School of Ageing Research.

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