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Review
. 2023 Dec;20(6):333-344.
doi: 10.1007/s11904-023-00680-y. Epub 2023 Dec 5.

Awareness of Heightened Sexual and Behavioral Vulnerability as a Trigger for PrEP Resumption Among Adolescent Girls and Young Women in East and Southern Africa

Krishnaveni Reddy  1 , Thesla Palanee-Phillips  2   3 , Renee Heffron  4
Affiliations
Review

Awareness of Heightened Sexual and Behavioral Vulnerability as a Trigger for PrEP Resumption Among Adolescent Girls and Young Women in East and Southern Africa

Krishnaveni Reddy et al. Curr HIV/AIDS Rep. 2023 Dec.

Abstract

Purpose of review: East and Southern Africa are the epicenter of the HIV epidemic. High HIV incidence rates among adolescent girls and young women (AGYW) remain stable over the last decade despite access to daily oral PrEP. Some settings have experienced high PrEP uptake among AGYW; however, discontinuation has been high. This review sought to understand drivers of PrEP discontinuation in this population in order to identify potential mechanisms to facilitate PrEP restart and optimize PrEP use.

Recent findings: Drivers of PrEP discontinuation included low perceived HIV acquisition risk, PrEP-associated side effects, pill burden, family/sexual partner disapproval, lack of/intermittent sexual activity, PrEP use stigma, fear of intimate partner violence, misinformation about long-term PrEP use, and limited/inconsistent access to PrEP. The most frequently reported driver of PrEP discontinuation was low perceived HIV acquisition risk. This indicates that innovative interventions to help AGYW recognize their HIV risk and make informed decisions about PrEP use are urgently needed.

Keywords: Adolescents; HIV vulnerability; Oral PrEP; Restart.

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Conflict of interest statement

K. Reddy, Prof. Renee Heffron and Prof. Thesla Palanee-Phillips declare that they have no conflict of interest.

Figures

Fig. 1
Fig. 1
Reasons for AGYW oral PrEP non-use/discontinuation categorized using the socioecological framework
See this image and copyright information in PMC

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