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Review
. 2024 Jan;1879(1):189037.
doi: 10.1016/j.bbcan.2023.189037. Epub 2023 Dec 2.

Dual role of Snail1 as transcriptional repressor and activator

Antonio García de Herreros  1
Affiliations
Review

Dual role of Snail1 as transcriptional repressor and activator

Antonio García de Herreros. Biochim Biophys Acta Rev Cancer. 2024 Jan.

Abstract

Snail1 transcriptional factor plays a key role in the control of epithelial to mesenchymal transition, a process that remodels tumor cells increasing their invasion and chemo-resistance as well as reprograms their metabolism and provides stemness properties. During this transition, Snail1 acts as a transcriptional repressor and, as growing evidences have demonstrated, also as a direct activator of mesenchymal genes. In this review, I describe the different proteins that interact with Snail1 and are responsible for these two different functions on gene expression; I focus on the transcriptional factors that associate to Snail1 in their target promoters, both activated and repressed. I also present working models for Snail1 action both as repressor and activator and raise some issues that still need to be investigated.

Keywords: EMT; Gene activation; Gene repression; Snail1.

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Conflict of interest statement

Declaration of Competing Interest The author declares that there are no conflicts of interest.

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