Lipocalin 2-A bone-derived anorexigenic and β-cell promoting signal: From mice to humans

doi:10.1111/1753-0407.13504

Review

. 2024 Mar;16(3):e13504.

doi: 10.1111/1753-0407.13504. Epub 2023 Nov 30.

Lipocalin 2-A bone-derived anorexigenic and β-cell promoting signal: From mice to humans

Yuying Yang^{1

2}, Jianmin Liu^{1

2}, Stavroula Kousteni³

Affiliations

¹ Department of Endocrine and Metabolic Diseases, Rui-jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Institute of Endocrine and Metabolic Diseases, and Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai, China.
² Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Clinical Research Center for Metabolic Diseases, Shanghai National Center for Translational Medicine, Rui-jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
³ Department of Physiology and Cellular Biophysics, Columbia University Medical Center, New York, New York, USA.

PMID: 38035773
PMCID: PMC10940901
DOI: 10.1111/1753-0407.13504

Review

Lipocalin 2-A bone-derived anorexigenic and β-cell promoting signal: From mice to humans

Yuying Yang et al. J Diabetes. 2024 Mar.

. 2024 Mar;16(3):e13504.

doi: 10.1111/1753-0407.13504. Epub 2023 Nov 30.

Authors

Yuying Yang^{1

2}, Jianmin Liu^{1

2}, Stavroula Kousteni³

Affiliations

¹ Department of Endocrine and Metabolic Diseases, Rui-jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Institute of Endocrine and Metabolic Diseases, and Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai, China.
² Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Clinical Research Center for Metabolic Diseases, Shanghai National Center for Translational Medicine, Rui-jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
³ Department of Physiology and Cellular Biophysics, Columbia University Medical Center, New York, New York, USA.

PMID: 38035773
PMCID: PMC10940901
DOI: 10.1111/1753-0407.13504

Abstract

The skeleton is traditionally known for its structural support, organ protection, movement, and maintenance of mineral homeostasis. Over the last 10 years, bone has emerged as an endocrine organ with diverse physiological functions. The two key molecules in this context are fibroblast growth factor 23 (FGF23), secreted by osteocytes, and osteocalcin, a hormone produced by osteoblasts. FGF23 affects mineral homeostasis through its actions on the kidneys, and osteocalcin has beneficial effects in improving glucose homeostasis, muscle function, brain development, cognition, and male fertility. In addition, another osteoblast-derived hormone, lipocalin 2 (LCN2) has emerged into the researchers' field of vision. In this review, we mainly focus on LCN2's role in appetite regulation and glucose metabolism and also briefly introduce its effects in other pathophysiological conditions, such as nonalcoholic fatty liver disease, sarcopenic obesity, and cancer-induced cachexia.

Keywords: Lipocalin-2; MC4R; appetite; energy metabolism; β-cell.

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Cited by

Bone: A Neglected Endocrine Organ?
Szeliga A, Grymowicz M, Kostrzak A, Smolarczyk R, Bala G, Smolarczyk K, Meczekalski B, Suchta K. Szeliga A, et al. J Clin Med. 2024 Jul 2;13(13):3889. doi: 10.3390/jcm13133889. J Clin Med. 2024. PMID: 38999458 Free PMC article. Review.

References

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1. Lee NK, Sowa H, Hinoi E, et al. Endocrine regulation of energy metabolism by the skeleton. Cell. 2007;130(3):456‐469. doi:10.1016/j.cell.2007.05.047 - DOI - PMC - PubMed
1. Khrimian L, Obri A, Karsenty G. Modulation of cognition and anxiety‐like behavior by bone remodeling. Mol Metab. 2017;6(12):1610‐1615. doi:10.1016/j.molmet.2017.10.001 - DOI - PMC - PubMed
1. Mera P, Laue K, Wei J, Berger JM, Karsenty G. Osteocalcin is necessary and sufficient to maintain muscle mass in older mice. Mol Metab. 2016;5(10):1042‐1047. doi:10.1016/j.molmet.2016.07.002 - DOI - PMC - PubMed
1. Oury F, Khrimian L, Denny CA, et al. Maternal and offspring pools of osteocalcin influence brain development and functions. Cell. 2013;155(1):228‐241. doi:10.1016/j.cell.2013.08.042 - DOI - PMC - PubMed

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[1] Bhattacharyya N, Chong WH, Gafni RI, Collins MT. Fibroblast growth factor 23: state of the field and future directions. Trends Endocrinol Metab. 2012;23(12):610‐618. doi:10.1016/j.tem.2012.07.002 - DOI - PMC - PubMed

[2] Bhattacharyya N, Chong WH, Gafni RI, Collins MT. Fibroblast growth factor 23: state of the field and future directions. Trends Endocrinol Metab. 2012;23(12):610‐618. doi:10.1016/j.tem.2012.07.002 - DOI - PMC - PubMed

[3] Lee NK, Sowa H, Hinoi E, et al. Endocrine regulation of energy metabolism by the skeleton. Cell. 2007;130(3):456‐469. doi:10.1016/j.cell.2007.05.047 - DOI - PMC - PubMed

[4] Lee NK, Sowa H, Hinoi E, et al. Endocrine regulation of energy metabolism by the skeleton. Cell. 2007;130(3):456‐469. doi:10.1016/j.cell.2007.05.047 - DOI - PMC - PubMed

[5] Khrimian L, Obri A, Karsenty G. Modulation of cognition and anxiety‐like behavior by bone remodeling. Mol Metab. 2017;6(12):1610‐1615. doi:10.1016/j.molmet.2017.10.001 - DOI - PMC - PubMed

[6] Khrimian L, Obri A, Karsenty G. Modulation of cognition and anxiety‐like behavior by bone remodeling. Mol Metab. 2017;6(12):1610‐1615. doi:10.1016/j.molmet.2017.10.001 - DOI - PMC - PubMed

[7] Mera P, Laue K, Wei J, Berger JM, Karsenty G. Osteocalcin is necessary and sufficient to maintain muscle mass in older mice. Mol Metab. 2016;5(10):1042‐1047. doi:10.1016/j.molmet.2016.07.002 - DOI - PMC - PubMed

[8] Mera P, Laue K, Wei J, Berger JM, Karsenty G. Osteocalcin is necessary and sufficient to maintain muscle mass in older mice. Mol Metab. 2016;5(10):1042‐1047. doi:10.1016/j.molmet.2016.07.002 - DOI - PMC - PubMed

[9] Oury F, Khrimian L, Denny CA, et al. Maternal and offspring pools of osteocalcin influence brain development and functions. Cell. 2013;155(1):228‐241. doi:10.1016/j.cell.2013.08.042 - DOI - PMC - PubMed

[10] Oury F, Khrimian L, Denny CA, et al. Maternal and offspring pools of osteocalcin influence brain development and functions. Cell. 2013;155(1):228‐241. doi:10.1016/j.cell.2013.08.042 - DOI - PMC - PubMed

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Lipocalin 2-A bone-derived anorexigenic and β-cell promoting signal: From mice to humans

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Lipocalin 2-A bone-derived anorexigenic and β-cell promoting signal: From mice to humans

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