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. 2023 Oct 29;9(11):e21761.
doi: 10.1016/j.heliyon.2023.e21761. eCollection 2023 Nov.

Effect of a lifestyle intervention program's on breast cancer survivors' cardiometabolic health: Two-year follow-up

Valentina Natalucci  1 , Carlo Ferri Marini  1 , Francesco Lucertini  1 , Giosuè Annibalini  1 , Davide Sisti  1 , Luciana Vallorani  1 , Roberta Saltarelli  1 , Andrea Rocco Panico  1 , Marta Imperio  1 , Marco Flori  2 , Paolo Busacca  2 , Anna Villarini  3 , Sabrina Donati Zeppa  1 , Deborah Agostini  1 , Silvia Monaldi  4 , Simone Barocci  5 , Vincenzo Catalano  4 , Marco Bruno Luigi Rocchi  1 , Piero Benelli  1 , Vilberto Stocchi  6 , Elena Barbieri  1 , Rita Emili  4
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Effect of a lifestyle intervention program's on breast cancer survivors' cardiometabolic health: Two-year follow-up

Valentina Natalucci et al. Heliyon. .

Abstract

The purpose of this study is to assess the cardiometabolic responses of a lifestyle intervention (LI) conducted at home among breast cancer (BC) survivors during the two years of COVID-19 pandemic. A 3-month LI focused on diet and exercise was performed on thirty BC survivors (women; stages 0-II; non-metastatic; aged 53.6 ± 7.6 years; non-physically active) with a risk factor related to metabolic/endocrine diseases. Anthropometrics, cardiorespiratory fitness (V˙O2max), physical activity level (PAL), adherence to the Mediterranean diet (MeDiet modified questionnaire), and several biomarkers (i.e., glycemia, insulin, insulin resistance [HOMA-IR] index, triglycerides, high- [HDL] and low- [LDL] density lipoproteins, total cholesterol, progesterone, testosterone, and hs-troponin) were evaluated before and 3-, 6-, 12-, and 24-month after the LI. Beneficial effects of the LI were observed on several variables (i.e., body mass index, waist circumference, MeDiet, PAL, V˙ O2max, glycemia, insulin, HOMA-IR index, LDL, total cholesterol, triglycerides, testosterone) after 3-month. The significant effect on Mediterranean diet adherence and V˙ O2max persisted up to the 24-month follow-up. Decreases in HOMA-IR index and triglycerides were observed up to 12-month, however did not persist afterward. This study provides evidence on the positive association between LI and cardiometabolic health in BC survivors.

Keywords: Aerobic exercise; Breast cancer survivors; COVID-19; Home-based lifestyle intervention; Mediterranean diet.

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Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Fig. 1
Fig. 1
Study design flowchart. HRR, heart rate reserve; on-site (OS) and remotely (RS) supervised; RSadpt, adapted remote supervision due to COVID-19 pandemic; follow-ups after 3 (T1), 6 (T2),12 (T3), and 24 (T4) months.
See this image and copyright information in PMC

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