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Review
. 2023 Nov 28;72(5):565-574.
doi: 10.33549/physiolres.935143.

Cellular and Molecular Connections Between Bone Fracture Healing and Exosomes

S Lv  1 , G Wang, L Dai, T Wang, F Wang
Affiliations
Review

Cellular and Molecular Connections Between Bone Fracture Healing and Exosomes

S Lv et al. Physiol Res. .

Abstract

Fracture healing is a multifaceted process that requires various phases and intercellular interactions. In recent years, investigations have been conducted to assess the feasibility of utilizing exosomes, small extracellular vesicles (EVs), to enhance and accelerate the healing process. Exosomes serve as a cargo transport platform, facilitating intercellular communication, promoting the presentation of antigens to dendritic cells, and stimulating angiogenesis. Exosomes have a special structure that gives them a special function, especially in the healing process of bone injuries. This article provides an overview of cellular and molecular processes associated with bone fracture healing, as well as a survey of existing exosome research in this context. We also discuss the potential use of exosomes in fracture healing, as well as the obstacles that must be overcome to make this a viable clinical practice.

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Conflict of interest statement

Conflict of Interest: There is no conflict of interest.

Figures

Fig. 1
Fig. 1
Compositions of EVs. The mechanisms of EV biogenesis are significantly related to their compositions and functions [21]. They act as endogenous delivery systems for intracellular communication, transporting proteins, lipids, metabolites, and nucleic acids while influencing various aspects of cell life.
Fig. 2
Fig. 2
Exosomes regulate the differentiation process of osteoblasts and bone fracture healing.
See this image and copyright information in PMC

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