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Review
. 2024;24(17):1602-1629.
doi: 10.2174/0113895575277122231108095511.

A Literature Review Focusing on the Antiviral Activity of [1,2,4] and [1,2,3]-triazoles

Thoraya A Farghaly  1 , Ghada S Masaret  1 , Sayed M Riyadh  2 , Marwa F Harras  3
Affiliations
Review

A Literature Review Focusing on the Antiviral Activity of [1,2,4] and [1,2,3]-triazoles

Thoraya A Farghaly et al. Mini Rev Med Chem. 2024.

Abstract

Out of a variety of heterocycles, triazole scaffolds have been shown to play a significant part in a wide array of biological functions. Many drug compounds containing a triazole moiety with important antimicrobial, anticancer and antidepressant properties have been commercialized. In addition, the triazole scaffold exhibits remarkable antiviral activity either incorporated into nucleoside analogs or non-nucleosides. Many synthetic techniques have been produced by scientists around the world as a result of their wide-ranging biological function. In this review, we have tried to summarize new synthetic methods produced by diverse research groups as well as provide a comprehensive description of the function of [1,2,4] and [1,2,3]-triazole derivatives as antiviral agents. Antiviral triazole compounds have been shown to target a wide variety of molecular proteins. In addition, several strains of viruses, including the human immunodeficiency virus, SARS virus, hepatitis B and C viruses, influenza virus, Hantavirus, and herpes virus, were discovered to be susceptible to triazole derivatives. This review article covered the reports for antiviral activity of both 1,2,3- and 1,2,4-triazole moieties up to 2022.

Keywords: 1; 2; 3-triazoles; 4-triazoles; Antiviral activity; COVID-19; HCV; heterocycles..

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