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Editorial
. 2023 Oct 29;14(11):2020.
doi: 10.3390/genes14112020.

RNA Splicing in Cancer and Targeted Therapies

Md Rafikul Islam  1   2 , Preeti Nagar  1   2 , Shegufta Tasneem Neetole  1 , Ledong Wan  3 , Mohammad Alinoor Rahman  1   2
Affiliations
Editorial

RNA Splicing in Cancer and Targeted Therapies

Md Rafikul Islam et al. Genes (Basel). .

Abstract

Since the discovery of RNA splicing as a fundamental step to remove introns from pre-mRNA to produce mature mRNAs, substantial research in the past decades has highlighted RNA splicing as a critical mediator of gene expression and proteome diversity, also being important in many developmental and biological processes [...].

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Conflict of interest statement

The authors declare no conflict of interest.

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References

    1. Bradley R.K., Anczuków O. RNA splicing dysregulation and the hallmarks of cancer. Nat. Rev. Cancer. 2023;23:135–155. doi: 10.1038/s41568-022-00541-7. - DOI - PMC - PubMed
    1. Rahman M.A., Krainer A.R., Abdel-Wahab O. SnapShot: Splicing Alterations in Cancer. Cell. 2020;180:208. doi: 10.1016/j.cell.2019.12.011. - DOI - PMC - PubMed
    1. Wan L., Deng M., Zhang H. SR Splicing Factors Promote Cancer via Multiple Regulatory Mechanisms. Genes. 2022;13:1659. doi: 10.3390/genes13091659. - DOI - PMC - PubMed
    1. Piazzi M., Bavelloni A., Salucci S., Faenza I., Blalock W.L. Alternative Splicing, RNA Editing, and the Current Limits of Next Generation Sequencing. Genes. 2023;14:1386. doi: 10.3390/genes14071386. - DOI - PMC - PubMed
    1. Xu R.-Y., Ding Z., Zhao Q., Ke T.-Y., Chen S., Wang X.-Y., Wang Y.-Y., Sheng M.-F., Wang W., Long N., et al. An Alternatively Spliced Variant of METTL3 Mediates Tumor Suppression in Hepatocellular Carcinoma. Genes. 2022;13:669. doi: 10.3390/genes13040669. - DOI - PMC - PubMed

Grants and funding

M.A.R. was supported by the Edward P. Evans Foundation, the Winthrop P. Rockefeller Cancer Institute, and the Arkansas Breast Cancer Research Program.

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