The Hallmarks of Circulating Hybrid Cells

doi:10.1007/978-3-031-37936-9_21

Review

. 2024:71:467-485.

doi: 10.1007/978-3-031-37936-9_21.

The Hallmarks of Circulating Hybrid Cells

Affiliations

¹ Department of Surgery, Oregon Health & Science University, Portland, OR, USA.
² Department of Cell, Developmental and Cancer Biology, Oregon Health & Science University, Portland, OR, USA.
³ Molecular Imaging Program at Stanford (MIPS), Department of Radiology, Stanford University School of Medicine, Palo Alto, CA, USA.
⁴ Department of Cell, Developmental and Cancer Biology, Oregon Health & Science University, Portland, OR, USA. wongme@ohsu.edu.
⁵ Knight Cancer Institute, Oregon Health & Science University, Portland, OR, USA. wongme@ohsu.edu.

^# Contributed equally.

PMID: 37996690
DOI: 10.1007/978-3-031-37936-9_21

Review

The Hallmarks of Circulating Hybrid Cells

Ranish K Patel et al. Results Probl Cell Differ. 2024.

. 2024:71:467-485.

doi: 10.1007/978-3-031-37936-9_21.

Authors

Affiliations

¹ Department of Surgery, Oregon Health & Science University, Portland, OR, USA.
² Department of Cell, Developmental and Cancer Biology, Oregon Health & Science University, Portland, OR, USA.
³ Molecular Imaging Program at Stanford (MIPS), Department of Radiology, Stanford University School of Medicine, Palo Alto, CA, USA.
⁴ Department of Cell, Developmental and Cancer Biology, Oregon Health & Science University, Portland, OR, USA. wongme@ohsu.edu.
⁵ Knight Cancer Institute, Oregon Health & Science University, Portland, OR, USA. wongme@ohsu.edu.

^# Contributed equally.

PMID: 37996690
DOI: 10.1007/978-3-031-37936-9_21

Abstract

While tumor metastases represent the primary driver of cancer-related mortality, our understanding of the mechanisms that underlie metastatic initiation and progression remains incomplete. Recent work identified a novel tumor-macrophage hybrid cell population, generated through the fusion between neoplastic and immune cells. These hybrid cells are detected in primary tumor tissue, peripheral blood, and in metastatic sites. In-depth analyses of hybrid cell biology indicate that they can exploit phenotypic properties of both parental tumor and immune cells, in order to intravasate into circulation, evade the immune response, and seed tumors at distant sites. Thus, it has become increasingly evident that the development and dissemination of tumor-immune hybrid cells play an intricate and fundamental role in the metastatic cascade and can provide invaluable information regarding tumor characteristics and patient prognostication. In this chapter, we review the current understanding of this novel hybrid cell population, the specific hallmarks of cancer that these cells exploit to promote cancer progression and metastasis, and discuss exciting new frontiers that remain to be explored.

Keywords: Cellular fusion; Hallmarks of cancer; Macrophage; Metastasis; Neoplastic-immune cell hybrid; Tumor.

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Cited by

Exploratory Analyses of Circulating Neoplastic-Immune Hybrid Cells as Prognostic Biomarkers in Advanced Intrahepatic Cholangiocarcinoma.
Patel RK, Parappilly MS, Walker BS, Heussner RT, Fung A, Chang YH, Kardosh A, Lopez CD, Mayo SC, Wong MH. Patel RK, et al. Int J Mol Sci. 2024 Aug 24;25(17):9198. doi: 10.3390/ijms25179198. Int J Mol Sci. 2024. PMID: 39273147 Free PMC article. Clinical Trial.

References

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[1] Aichel O (1911) Über Zellverschmelzung mit qualitativ abnormer Chromosomenverteilung als Ursache der Geschwulstbildung, vol 13. W. Engelmann, Leipzig

[2] Aichel O (1911) Über Zellverschmelzung mit qualitativ abnormer Chromosomenverteilung als Ursache der Geschwulstbildung, vol 13. W. Engelmann, Leipzig

[3] Allan AL, Vantyghem SA, Tuck AB, Chambers AF, Chin-Yee IH, Keeney M (2005) Detection and quantification of circulating tumor cells in mouse models of human breast cancer using immunomagnetic enrichment and multiparameter flow cytometry. Cytometry A 65(1):4–14. https://doi.org/10.1002/cyto.a.20132 - DOI - PubMed

[4] Allan AL, Vantyghem SA, Tuck AB, Chambers AF, Chin-Yee IH, Keeney M (2005) Detection and quantification of circulating tumor cells in mouse models of human breast cancer using immunomagnetic enrichment and multiparameter flow cytometry. Cytometry A 65(1):4–14. https://doi.org/10.1002/cyto.a.20132 - DOI - PubMed

[5] Avilès D, Jami J, Rousset JP, Ritz E (1977) Tumor x host cell hybrids in the mouse: chromosomes from the normal cell parent maintained in malignant hybrid tumors. J Natl Cancer Inst 58(5):1391–1399. https://doi.org/10.1093/jnci/58.5.1391 - DOI - PubMed

[6] Avilès D, Jami J, Rousset JP, Ritz E (1977) Tumor x host cell hybrids in the mouse: chromosomes from the normal cell parent maintained in malignant hybrid tumors. J Natl Cancer Inst 58(5):1391–1399. https://doi.org/10.1093/jnci/58.5.1391 - DOI - PubMed

[7] Ben-David U, Amon A (2020) Context is everything: aneuploidy in cancer. Nat Rev Genet 21(1):44–62. https://doi.org/10.1038/s41576-019-0171-x - DOI - PubMed

[8] Ben-David U, Amon A (2020) Context is everything: aneuploidy in cancer. Nat Rev Genet 21(1):44–62. https://doi.org/10.1038/s41576-019-0171-x - DOI - PubMed

[9] Boveri T (2008) Concerning the origin of malignant tumours by Theodor Boveri. Translated and annotated by Henry Harris. J Cell Sci 121 Suppl 1:1–84. https://doi.org/10.1242/jcs.025742 - DOI - PubMed

[10] Boveri T (2008) Concerning the origin of malignant tumours by Theodor Boveri. Translated and annotated by Henry Harris. J Cell Sci 121 Suppl 1:1–84. https://doi.org/10.1242/jcs.025742 - DOI - PubMed

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The Hallmarks of Circulating Hybrid Cells

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The Hallmarks of Circulating Hybrid Cells

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