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Review
. 2024 Feb;1870(2):166962.
doi: 10.1016/j.bbadis.2023.166962. Epub 2023 Nov 19.

Arming oncolytic viruses with bispecific T cell engagers: The evolution and current status

Yunmeng Wang  1 , Ping Cheng  2
Affiliations
Review

Arming oncolytic viruses with bispecific T cell engagers: The evolution and current status

Yunmeng Wang et al. Biochim Biophys Acta Mol Basis Dis. 2024 Feb.

Abstract

Oncolytic viruses (OVs) are emerging as therapeutically relevant anticancer agents as contemporary immunotherapy gains traction. Furthermore, OVs are an ideal platform for genetic modification to express therapeutic transgenes. Bispecific T cell engagers (BiTEs) can redirect T cells to tumor cells, resulting in targeted cytotoxicity. BiTEs have demonstrated success in hematological cancers but are rarely used in solid tumors. The drawbacks of BiTEs, including inadequate delivery and on-target-off-tumor activity have limited their efficacy. Combining OVs with BiTEs is a prospective area to investigate. This combined strategy can benefit from the best qualities of both therapies while overcoming the limitations.

Keywords: Bispecific T cell engagers; Combination therapy; Immunotherapy; Oncolytic viruses.

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Conflict of interest statement

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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