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. 2023 Nov 17;72(46):1262-1268.
doi: 10.15585/mmwr.mm7246a3.

Progress Toward Measles Elimination - Worldwide, 2000-2022

Anna A Minta, Matt Ferrari, Sebastien Antoni, Allison Portnoy, Alyssa Sbarra, Brian Lambert, Cynthia Hatcher, Christopher H Hsu, Lee Lee Ho, Claudia Steulet, Marta Gacic-Dobo, Paul A Rota, Mick N Mulders, Anindya Sekhar Bose, William Perea Caro, Patrick O'Connor, Natasha S Crowcroft

Progress Toward Measles Elimination - Worldwide, 2000-2022

Anna A Minta et al. MMWR Morb Mortal Wkly Rep. .

Abstract

Measles is a highly contagious, vaccine-preventable disease that requires high population immunity for transmission to be interrupted. All six World Health Organization regions have committed to eliminating measles; however, no region has achieved and sustained measles elimination. This report describes measles elimination progress during 2000-2022. During 2000-2019, estimated coverage worldwide with the first dose of measles-containing vaccine (MCV) increased from 72% to 86%, then declined to 81% in 2021 during the COVID-19 pandemic, representing the lowest coverage since 2008. In 2022, first-dose MCV coverage increased to 83%. Only one half (72) of 144 countries reporting measles cases achieved the measles surveillance indicator target of two or more discarded cases per 100,000 population in 2022. During 2021-2022, estimated measles cases increased 18%, from 7,802,000 to 9,232,300, and the number of countries experiencing large or disruptive outbreaks increased from 22 to 37. Estimated measles deaths increased 43% during 2021-2022, from 95,000 to 136,200. Nonetheless, an estimated 57 million measles deaths were averted by vaccination during 2000-2022. In 2022, measles vaccination coverage and global surveillance showed some recovery from the COVID-19 pandemic setbacks; however, coverage declined in low-income countries, and globally, years of suboptimal immunization coverage left millions of children unprotected. Urgent reversal of coverage setbacks experienced during the COVID-19 pandemic can be accomplished by renewing efforts to vaccinate all children with 2 MCV doses and strengthening surveillance, thereby preventing outbreaks and accelerating progress toward measles elimination.

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Conflict of interest statement

All authors have completed and submitted the International Committee of Medical Journal Editors form for disclosure of potential conflicts of interest. Matt Ferrari reports institutional support and contracts from Gavi, the Vaccine Alliance and the Bill and Melinda Gates Foundation, and travel support to attend meetings from the Bill and Melinda Gates Foundation. Lee Lee Ho reports consulting fees from the World Health Organization. Alyssa Sbarra reports institutional support from the Bill and Melinda Gates Foundation and receipt of a National Institutes of Health training grant, and contract support from the World Health Organization. No other potential conflicts of interest were disclosed.

Figures

FIGURE
FIGURE
Estimated number of annual measles deaths with measles vaccination and in the absence of measles vaccination — worldwide, 2000–2022, * With 95% CIs indicated by error bars. † Deaths prevented by vaccination are estimated by the area between estimated deaths with vaccination and those without vaccination. A cumulative total of 57 million deaths were estimated to have been prevented by vaccination during 2000–2022.
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