Imaging of Amyloid-beta-related Arteritis
- PMID: 37951701
- DOI: 10.1016/j.nic.2023.09.001
Imaging of Amyloid-beta-related Arteritis
Abstract
Cerebral amyloid angiopathy (CAA) is a cerebrovascular disorder marked by the accumulation of amyloid-beta peptide (Aβ) within the leptomeninges and smaller blood vessels of the brain. CAA can be both noninflammatory and inflammatory, and the inflammatory version includes Aβ-related angiitis (ABRA). ABRA is a vasculitis of the central nervous system related to an inflammatory response to Aβ in the vascular walls, which necessitates differentiating ABRA from noninflammatory CAA, as ABRA may require immunosuppressive treatment. MR imaging is typically the most effective imaging modality of choice to screen for these conditions, and they should be obtained at varying time points to track disease progression.
Keywords: Amyloid-related imaging abnormalities; Aβ-related angiitis; Cerebral amyloid angiopathy.
Copyright © 2023 Elsevier Inc. All rights reserved.
Conflict of interest statement
Disclosure Dr A. de Havenon has received investigator initiated clinical research funding from the AAN, has received consultant fees from Integra and Novo Nordisk, royalty fees from UpToDate, and has equity in TitinKM and Certus.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical