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Review
. 2023 Nov 3;102(44):e35695.
doi: 10.1097/MD.0000000000035695.

Interleukin-22 and acute pancreatitis: A review

Xinjuan Fu  1   2 , Zhigang Xiu  1 , Hongwei Xu  1   3
Affiliations
Review

Interleukin-22 and acute pancreatitis: A review

Xinjuan Fu et al. Medicine (Baltimore). .

Abstract

Acute pancreatitis (AP) is one of the most common gastrointestinal diseases, and it is divided into 3 types according to its severity:mild acute pancreatitis, moderately severe acute pancreatitis, and severe acute pancreatitis. The mortality in severe acute pancreatitis is approximately 15% to 30% due to multiorgan dysfunction and the lack of specific treatment. Interleukin-22 (IL-22) is a member of the Interleukin-10 family, and it can activate several downstream signaling pathways by binding to its receptor complex, thus it is involved in cell differentiation, proliferation, and apoptosis. Some studies have reported the elevated level of IL-22 in patients with AP, which suggests IL-22 may be involved in the pathogenesis of AP. And many studies have shown that IL-22 had a protective effect against AP. This article reviews the characteristics and mechanism of IL-22 and its role in AP to provide insight into the treatment of AP.

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Conflict of interest statement

The authors have no conflicts of interest to disclose.

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