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. 1986 Nov;50(5):861-74.
doi: 10.1016/S0006-3495(86)83527-5.

Repolarization currents in embryonic chick atrial heart cell aggregates

A Shrier, J R Clay

Repolarization currents in embryonic chick atrial heart cell aggregates

A Shrier et al. Biophys J. 1986 Nov.

Abstract

Outward membrane currents in aggregates of atrial cells prepared from 7-12-d-old chick embryonic hearts were measured with the two microelectrode voltage-clamp technique. Two outward current components, Ix1 and Ix2, were found in the plateau potential range of the action potential. The Ix1 component is activated between -50 and -20 mV; the Ix2 component is activated between -15 and +20 mV. The Ix1 component inwardly rectifies, whereas Ix2 has an approximately linear current-voltage relation. These preparations lack a time-dependent pacemaker current component, even though they beat spontaneously with an interbeat interval of approximately 1 s. A mathematical model of electrical activity is described based on our measurements of time-dependent outward current, and measurements in the literature of inward current components.

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