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Review
. 2023 Sep 28;16(10):1374.
doi: 10.3390/ph16101374.

Antioxidant Therapy in Inflammatory Bowel Disease: A Systematic Review and a Meta-Analysis of Randomized Clinical Trials

José Israel Rodrigues Junior  1 , Joice Kelly Gomes de Vasconcelos  1 , Lylian Ellen Militão Dos Santos Xavier  2 , Amanda da Silva Gomes  2 , Juliana Célia de Farias Santos  3 , Samara Bomfim Gomes Campos  1 , Amylly Sanuelly da Paz Martins  4 , Marília Oliveira Fonseca Goulart  4   5   6 , Fabiana Andréa Moura  2   3
Affiliations
Review

Antioxidant Therapy in Inflammatory Bowel Disease: A Systematic Review and a Meta-Analysis of Randomized Clinical Trials

José Israel Rodrigues Junior et al. Pharmaceuticals (Basel). .

Abstract

The objective of this study is to assess the effectiveness of treatment for inflammatory bowel diseases in modulating oxidative stress biomarkers and cytokine levels. A systematic review of clinical trials was conducted, searching electronic databases including PubMed, Science Direct, and Scopus. After excluding articles that did not meet the inclusion criteria, 19 studies were included in the systematic review and 8 in the meta-analysis (6 for antioxidant capacity, 6 for superoxide dismutase (SOD), and 5 for lipid peroxidation analyzed through malondialdehyde (MDA) levels). SOD was significantly modulated (RR = 0.3764, 95% CI [0.0262 to 0.7267], p = 0.035) but not antioxidant capacity (RR = 0.3424, 95% CI [0.0334 to 0.7183], p = 0.0742) or MDA (RR = -0.8534, 95% CI [-1.9333 to 0.2265], p = 0.1214). Nonetheless, studies investigating oxidative stress biomarkers and cytokines in the context of alternative therapies for IBD treatment are still scarce. This review highlights the potential of antioxidant supplementation in IBD management and underscores the need for further investigations into its effects on oxidative stress biomarkers and cytokines to improve therapeutic approaches for IBD patients.

Keywords: Crohn’s disease; cytokines; oxidative stress; ulcerative colitis.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Flow diagram of study selection.
Figure 2
Figure 2
Forest plot for antioxidant capacity induced by inflammatory bowel disease therapy, according to a randomized clinical trial included in the meta-analysis Legend: df (Degrees of Freedom); H2 (H-squared); Q: heterogeneity test; SE: standard error; Tau2 (Tau squared) [11,12,15,16,19,21].
Figure 3
Figure 3
Forest plot for superoxide dismutase induced by inflammatory bowel disease therapy, according to a randomized clinical trial included in the meta-analysis. Legend: df (Degrees of Freedom); H2 (H-squared); Q: heterogeneity test; SE: standard error; Tau2 (Tau squared) [11,12,19,20,21,26].
Figure 4
Figure 4
Forest plot for malondialdehyde induced by inflammatory bowel disease therapy, according to a randomized clinical trial included in the meta-analysis. Legend: df (Degrees of Freedom); H2 (H-squared); Q: heterogeneity test; SE: standard error; Tau2 (Tau squared) [11,12,15,16,19].
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