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Review
. 2023 Sep 25;11(10):2631.
doi: 10.3390/biomedicines11102631.

Focal Active Colitis: What Are Its Clinical Implications? A Narrative Review

Emanuele Sinagra  1 , Francesco Vito Mandarino  2 , Marcello Maida  3 , Daniela Cabibi  4 , Francesca Rossi  1 , Dario Raimondo  1 , Guido Manfredi  5 ; AIGO (Italian Association of Hospital Gastroenterologist) Young Committee
Affiliations
Review

Focal Active Colitis: What Are Its Clinical Implications? A Narrative Review

Emanuele Sinagra et al. Biomedicines. .

Abstract

Focal active colitis (FAC) is described as a histolopathological term indicating the isolated finding of focal neutrophil infiltration in the colonic crypts. Currently, there exist numerous debates regarding the clinical significance of diagnosing FAC, which may or may not have clinical relevance as it is frequently detected in colorectal biopsies without any other microscopic abnormalities. The objective of this narrative review is to provide an overview of the available evidence concerning the clinical implications of FAC, both in the adult population (among five studies available in the scientific literature) and in the pediatric context (based on two available studies).

Keywords: Crohn’s disease; focal active colitis; indeterminate colitis; self-limiting colitis; ulcerative colitis.

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Conflict of interest statement

The authors declare no conflict of interest.

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