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Review
. 2023 Oct;41(10):1945-1954.
doi: 10.55563/clinexprheumatol/7kdo9x. Epub 2023 Oct 10.

Behçet's syndrome: one year in review 2023

Gülen Hatemi  1 , Emire Seyahi  1 , Izzet Fresko  1 , Rosaria Talarico  2 , Didar Uçar  3 , Vedat Hamuryudan  4
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Free article
Review

Behçet's syndrome: one year in review 2023

Gülen Hatemi et al. Clin Exp Rheumatol. 2023 Oct.
Free article

Abstract

This critical review of studies on Behçet's syndrome published during 2022 includes studies on epidemiology, patients' perspective, pathogenesis, diagnosis, clinical features and management. Studies on pathogenesis included potential biomarkers mostly related to macrophages, neutrophil and cytokine balance, new GWAS and polymorphism studies, and studies on miRNAs and long non-coding RNAs. Clinical studies showed that application of pneumococcal vaccine to the prick site increased the sensitivity and specificity of the pathergy test and the prevalence of AA amyloidosis had decreased over the years. Studies on management indicated that more data are needed to understand the effect of apremilast on BS manifestations other than oral ulcers, and new BS manifestations may develop during treatment with infliximab. Other biologics and Jak inhibitors might be an option for patients who are refractory to TNF-α inhibitors. Moreover, endovascular repair of arterial aneurysms might be an alternative to open surgery.

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