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Review
. 2024 Mar;25(3):212-222.
doi: 10.1038/s41580-023-00674-z. Epub 2023 Oct 23.

Activation of human endogenous retroviruses and its physiological consequences

Nicholas Dopkins  1 , Douglas F Nixon  2
Affiliations
Review

Activation of human endogenous retroviruses and its physiological consequences

Nicholas Dopkins et al. Nat Rev Mol Cell Biol. 2024 Mar.

Abstract

Human endogenous retroviruses (HERVs) are abundant sequences that persist within the human genome as remnants of ancient retroviral infections. These sequences became fixed and accumulate mutations or deletions over time. HERVs have affected human evolution and physiology by providing a unique repertoire of coding and non-coding sequences to the genome. In healthy individuals, HERVs participate in immune responses, formation of syncytiotrophoblasts and cell-fate specification. In this Review, we discuss how endogenized retroviral motifs and regulatory sequences have been co-opted into human physiology and how they are tightly regulated. Infections and mutations can derail this regulation, leading to differential HERV expression, which may contribute to pathologies including neurodegeneration, pathological inflammation and oncogenesis. Emerging evidence demonstrates that HERVs are crucial to human health and represent an understudied facet of many diseases, and we therefore argue that investigating their fundamental properties could improve existing therapies and help develop novel therapeutic strategies.

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References

    1. Nisole, S. & Saïb, A. Early steps of retrovirus replicative cycle. Retrovirology 1, 9 (2004). - PubMed - PMC - DOI
    1. Jern, P. & Coffin, J. M. Effects of retroviruses on host genome function. Annu. Rev. Genet. 42, 709–732 (2008). - PubMed - DOI
    1. de Parseval, N. & Heidmann, T. Human endogenous retroviruses: from infectious elements to human genes. Cytogenet. Genome Res. 110, 318–332 (2005). Together with Jern and Coffin (2008), this paper is a seminal review article that discusses in detail the foundational studies of endogenous retroviruses. - PubMed - DOI
    1. Nurk, S. et al. The complete sequence of a human genome. Science 376, 44–53 (2022). - PubMed - PMC - DOI
    1. Lander, E. S. et al. Initial sequencing and analysis of the human genome. Nature 409, 860–921 (2001). - PubMed - DOI

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