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Review
. 2024 Jan;108(1):116082.
doi: 10.1016/j.diagmicrobio.2023.116082. Epub 2023 Sep 7.

microRNA as biomarkers in tuberculosis: a new emerging molecular diagnostic solution

Piyush Agrawal  1 , Aditya Upadhyay  1 , Awanish Kumar  2
Affiliations
Review

microRNA as biomarkers in tuberculosis: a new emerging molecular diagnostic solution

Piyush Agrawal et al. Diagn Microbiol Infect Dis. 2024 Jan.

Abstract

Tuberculosis (TB) caused by Mycobacterium tuberculosis is a lethal infectious disease that is prevalent worldwide. During TB infection, host microRNAs change their expression in the form of up/down-regulation. The identification of unique host microRNAs during TB could serve as potential biomarkers in the early detection of TB. microRNAs fulfill the required criteria for being an ideal biomarker, such as sensitivity, high specificity, and accessibility. Therefore, the recognition of potential host microRNAs can be valuable for the diagnosis of TB. The field of miRNA biomarkers in TB requires more extensive research to identify potential biomarkers. This review provides an overview of the biogenesis and biological functions of microRNAs and presents the findings of various studies on the identification of potential biomarkers for TB. Research momentum is gaining in this field and we anticipate that miRNAs will become a routine approach in the development of reliable diagnostic and specific therapeutic interventions in future.

Keywords: Biomarker; Diagnostic; MicroRNAs; Therapeutic intervention; Tuberculosis.

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Conflict of interest statement

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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