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Meta-Analysis
. 2023 Oct 14;13(1):17457.
doi: 10.1038/s41598-023-44487-8.

Family history of cancer as a potential risk factor for colorectal cancer in EMRO countries: a systematic review and meta-analysis

Mohammad-Hossein Keivanlou  1   2 , Ehsan Amini-Salehi  1   2 , Farahnaz Joukar  1 , Negin Letafatkar  1   2 , Arman Habibi  1   2 , Naeim Norouzi  1   2 , Azin Vakilpour  3 , Maryam Sadat Aleali  1 , Zahra Rafat  4 , Mohammad Taghi Ashoobi  5 , Fariborz Mansour-Ghanaei  1 , Soheil Hassanipour  6
Affiliations
Meta-Analysis

Family history of cancer as a potential risk factor for colorectal cancer in EMRO countries: a systematic review and meta-analysis

Mohammad-Hossein Keivanlou et al. Sci Rep. .

Abstract

The current meta-analysis aims to investigate the existing articles that evaluated the implications of a positive family history of cancer on the risk of colorectal cancer (CRC) within the EMRO countries. We employed PubMed, Scopus, and Web of Science as search databases for this study. To assess the quality of the selected articles, we utilized the Newcastle-Ottawa (NCO) checklist. In comparing the impact of a family history of cancer between the case and control groups, we computed the odds ratio (OR) along with its corresponding 95% confidence interval (CI). Finally, 27 articles were selected for meta-analysis. The result of the meta-analysis showed a significant association between the presence of a family history of CRC or any cancers and CRC (OR 2.21; 95% CI 1.54-3.17; P < 0.001, OR 1.76; 95% CI 1.27-2.42; P = 0.001, respectively). Our findings underscore the critical importance of timely screening and early identification for individuals with a family history of cancer. By fostering close coordination among healthcare facilities and actively promoting the adoption of screening methods for early detection, we have the potential to significantly reduce both mortality rates and financial burdens of CRC on the general public, ultimately leading to enhanced patient outcomes.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
Newcastle–Ottawa (NCO) quality assessment scale for included studies is used to assessing the quality of included articles to see which study is methodologically better than the other one and how a low-quality article can impact on the main result.
Figure 2
Figure 2
Flow chart of study selection process to showed that all of our study selection process is done under the guidelines of Preferred Reporting Items for Systematic Reviews and Meta-Analysis.
Figure 3
Figure 3
(A) Forest plot for the relationship between positive family history of any cancer and colorectal cancer is performed to see if there is a positive relationship between a positive family history of any cancer and risk of colorectal cancer or not, (B) Forest plot for the relationship between positive family history of CRC cancer and colorectal cancer performed to see if there is a positive relationship between a positive family history of CRC and risk of colorectal cancer or not, (C) Forest plot for the relationship between positive family history of any cancer in first-degree relatives and colorectal cancer is performed to see people having a positive first-degree family history of any cancer can experience a higher risk of colorectal cancer than other types of positive family history of any cancer or not, (D) Forest plot for the relationship between positive family history of CRC in first-degree relatives and colorectal cancer is performed to see people having a positive first-degree family history of CRC can experience a higher risk of colorectal cancer than other types of positive family history of CRC or not.
Figure 4
Figure 4
(A) Result of sensitivity analysis by one study removing in CRC group to find the potential source of heterogeneity, (B) Result of sensitivity analysis by one study removing in any cancer group to find the potential source of heterogeneity, (C) Result of power analysis to find the source of heterogeneity in CRC relationship, (D) Result of power analysis to find the source of heterogeneity in any cancer relationship.
Figure 5
Figure 5
(A) Result of meta regression based on number of sample size in CRC group. This analysis is performed to see if there is a relationship between increasing number of sample size and risk of CRC among positive family history of CRC, (B) Result of meta regression based on number of sample size in any cancer group. This analysis is performed to see if there is a relationship between increasing number of sample size and risk of CRC among positive family history of any cancer, (C) Result of meta regression based on level of human developmental index (HDI) in CRC group. This analysis is performed to see if there is a relationship between increasing the rate of HDI and risk of CRC among positive family history of CRC, (D) Result of meta regression based on level of HDI in any cancer group. This analysis is performed to see if there is a relationship between increasing the rate of HDI and risk of CRC among positive family history of any cancer, (E) Funnel plot for assessing the source of heterogeneity in CRC group. This analysis is performed to find the source of Heterogeneity, (F) Funnel plot for assessing the source of heterogeneity in any cancer group. This analysis is performed to find the source of Heterogeneity.
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