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. 2023 Dec;33(12):2384-2388.
doi: 10.1016/j.numecd.2023.07.033. Epub 2023 Aug 3.

Carotid intima layer thickness but not intima-media thickness is related to coronary artery calcification in type 2 diabetes individuals: Results from the Brazilian diabetes study

Nestor S Martins  1 , Joaquim Barreto  2 , Sheila Tatsumi Kimura-Medorima  2 , Sofia Helena Vitte  3 , Thiago Quinaglia  2 , Barbara Assato  2 , Otavio Rizzi Coelho-Filho  1 , Jose Roberto Matos-Souza  1 , Wilson Nadruz  1 , Andrei C Sposito  4 ; Brazilian Heart Study Group
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Carotid intima layer thickness but not intima-media thickness is related to coronary artery calcification in type 2 diabetes individuals: Results from the Brazilian diabetes study

Nestor S Martins et al. Nutr Metab Cardiovasc Dis. 2023 Dec.

Abstract

Background and aims: Carotid intima-media thickness (cIMT) is inconsistent in predicting cardiovascular risk. This may stem from the variability of the media thickness (cM) outweighing the intimal thickness (cIT) as the sign of atherosclerosis. Thus, we evaluated in type 2 diabetes (T2D) individuals, the association between carotid measures and coronary artery calcification (CAC).

Methods and results: Association between the presence of CAC and cIT, cM, and cIMT were examined on 224 individuals. Logistic binary regression was used to assess CAC predictors. The Akaike information criterion (AIC) and log-likelihood test (LLT) were used to assess differences among univariate models. The cIT (0.335 mm vs 0.363 mm; p = 0.001) and cIMT (0.715 vs 0.730; p = 0.019), but not cM (0.386 mm vs 0,393 mm; p = 0.089) were higher among individuals with CAC. In unadjusted analysis, cIT (273;-134; p = 0.001) showed greater relationship with CAC, when compared to cIMT (279;-137; p = 0.022) and cM (281;-139; p = 0.112) based on the AIC and LLT, respectively. In multivariate logistic regression, CAC was related to carotid plaque (OR): 1.91, 95% confidence interval (CI):1.08, 3.38; p = 0.027), and high-cIT (OR: 2.70, 95%CI:1.51, 4.84; p = 0.001), but not to high-cIMT (OR:1.70, 95%CI:0.96, 3.00; p = 0.067) nor high-cM (OR:1.33, 95%CI:0.76, 2.34; p = 0.322).

Conclusion: In T2D individuals, cIT is a better predictor of CAC than cIMT; cM is not associated with CAC.

Keywords: Atherosclerosis; Carotid intima thickness; Coronary calcification; Diabetes.

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Conflict of interest statement

Declaration of competing interest The authors declare no known competing financial or personal interests that could influence this work.

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