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Review
. 2023 Sep 22;28(9):210.
doi: 10.31083/j.fbl2809210.

The Role of NLRP3 Inflammasomes in Trained Immunity

Gilyoung Lee  1 , Huijeong Ahn  1 , Eunsong Lee  1 , Geun-Shik Lee  1
Affiliations
Free article
Review

The Role of NLRP3 Inflammasomes in Trained Immunity

Gilyoung Lee et al. Front Biosci (Landmark Ed). .
Free article

Abstract

Inflammasomes are cytosolic multi-protein complexes that play an important role in the innate immune system, inducing cytokine maturation and pyroptosis. Trained immunity is the induction of memory in innate immune cells by epigenetic reprogramming due to repeated inflammatory stimuli that alter the inflammatory response and increase resistance to infection or disease. Although it is speculated that nucleotide-binding oligomerization domain (NOD), leucine-rich repeat (LRR), and the NLR family pyrin domain containing 3 (NLRP3) inflammasomes respond to various inflammatory stimuli and are associated with trained immunity, the exact relationship is still unclear. This paper aims to introduce data from recent research on the role of inflammasomes in trained immunity through cellular immunometabolic and epigenetic reprogramming. It also suggests a new therapeutic strategy for inflammatory diseases through the complementary regulation of inflammasomes and trained immunity.

Keywords: NLRP3; inflammasome; inflammatory diseases; trained immunity.

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Conflict of interest statement

The authors declare no conflict of interest. The Guest Editor, Geun-Shik Lee has not been involved in the peer-review of this article and has no access to information regarding its peer review. Full responsibility for the editorial process for this article was delegated to Amedeo Amedei.

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