Long-Term Exposure of Nitrogen Oxides Air Pollution (NO2) Impact for Coronary Artery Lesion Progression-Pilot Study

doi:10.3390/jpm13091376

. 2023 Sep 14;13(9):1376.

doi: 10.3390/jpm13091376.

Long-Term Exposure of Nitrogen Oxides Air Pollution (NO₂) Impact for Coronary Artery Lesion Progression-Pilot Study

Tomasz Urbanowicz¹, Krzysztof Skotak², Krzysztof J Filipiak^{3

4}, Anna Olasińska-Wiśniewska¹, Krystian Szczepański², Michał Wyrwa⁴, Jędrzej Sikora⁵, Andrzej Tykarski⁴, Marek Jemielity¹

Affiliations

¹ Cardiac Surgery and Transplantology Department, Poznan University of Medical Sciences, 61-701 Poznan, Poland.
² Institute of Environmental Protection, National Research Institute, 01-045 Warsaw, Poland.
³ Institute of Clinical Science, Maria Sklodowska-Curie Medical Academy, 00-136 Warsaw, Poland.
⁴ Department of Hypertensiology, Angiology and Internal Medicine, Poznań University of Medical Sciences, 61-701 Poznan, Poland.
⁵ Poznań University of Medical Sciences, 61-701 Poznan, Poland.

PMID: 37763144
PMCID: PMC10532770
DOI: 10.3390/jpm13091376

Long-Term Exposure of Nitrogen Oxides Air Pollution (NO₂) Impact for Coronary Artery Lesion Progression-Pilot Study

Tomasz Urbanowicz et al. J Pers Med. 2023.

. 2023 Sep 14;13(9):1376.

doi: 10.3390/jpm13091376.

Authors

Affiliations

¹ Cardiac Surgery and Transplantology Department, Poznan University of Medical Sciences, 61-701 Poznan, Poland.
² Institute of Environmental Protection, National Research Institute, 01-045 Warsaw, Poland.
³ Institute of Clinical Science, Maria Sklodowska-Curie Medical Academy, 00-136 Warsaw, Poland.
⁴ Department of Hypertensiology, Angiology and Internal Medicine, Poznań University of Medical Sciences, 61-701 Poznan, Poland.
⁵ Poznań University of Medical Sciences, 61-701 Poznan, Poland.

PMID: 37763144
PMCID: PMC10532770
DOI: 10.3390/jpm13091376

Abstract

Background: The potentially harmful effects of air pollution on the human health have been already presented in epidemiological studies, suggesting a strong association with increased morbidity and mortality. The aim of the study was to evaluate a possible relationship between coronary artery lesion progression related to habitation place (cities vs. villages) and air pollution.

Methods: There were 148 (101 men and 47 women) patients with a median age of 70 (63-74) years enrolled into retrospective analysis based on the coronary angiography results and their habitation place. Patients with stable coronary syndrome, who underwent repeated percutaneous coronary interventions were enrolled into the analysis based on demographical and clinical characteristics combined with annual exposure to air pollution (PM2.5, PM10, and NO₂).

Results: The results of multivariable regression analysis showed a significant relationship between coronary artery lesion progression requiring percutaneous intervention and NO₂ chronic exposure in patients living in cities of Poland (OR 2.00, 95% CI: 0.41-9.62, p < 0.001). The predictive value of air pollution exposure at habitation place for coronary artery lesion progression requiring percutaneous intervention was evaluated by receiver-operator curve analysis, which revealed an area under the curve of 0.939, yielding a sensitivity of 87.1% and specificity of 90.7%.

Conclusions: Coronary artery lesion progression can be related to chronic exposure to NO₂ air pollution in patients living in cities in Poland.

Keywords: CAD; NO2; PM10; PM2.5; air pollution.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

**Figure 1**
Receiver-operator curve for mean NO₂ exposure in coronary artery disease patients’ living in cities.

See this image and copyright information in PMC

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References

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[1] Duggan J.P., Peters A.S., Trachiotis G.D., Antevil J.L. Epidemiology of Coronary Artery Disease. Surg. Clin. N. Am. 2022;102:499–516. doi: 10.1016/j.suc.2022.01.007. - DOI - PubMed

[2] Duggan J.P., Peters A.S., Trachiotis G.D., Antevil J.L. Epidemiology of Coronary Artery Disease. Surg. Clin. N. Am. 2022;102:499–516. doi: 10.1016/j.suc.2022.01.007. - DOI - PubMed

[3] Cleven L., Krell-Roesch J., Nigg C.R., Woll A. The association between physical activity with incident obesity, coronary heart disease, diabetes and hypertension in adults: A systematic review of longitudinal studies published after 2012. BMC Public Health. 2020;20:726–741. doi: 10.1186/s12889-020-08715-4. - DOI - PMC - PubMed

[4] Cleven L., Krell-Roesch J., Nigg C.R., Woll A. The association between physical activity with incident obesity, coronary heart disease, diabetes and hypertension in adults: A systematic review of longitudinal studies published after 2012. BMC Public Health. 2020;20:726–741. doi: 10.1186/s12889-020-08715-4. - DOI - PMC - PubMed

[5] Simonetto C., Rospleszcz S., Kaiser J.C., Furukawa K. Heterogeneity in coronary heart disease risk. Sci. Rep. 2022;12:10131–10140. doi: 10.1038/s41598-022-14013-3. - DOI - PMC - PubMed

[6] Simonetto C., Rospleszcz S., Kaiser J.C., Furukawa K. Heterogeneity in coronary heart disease risk. Sci. Rep. 2022;12:10131–10140. doi: 10.1038/s41598-022-14013-3. - DOI - PMC - PubMed

[7] Malakar A.K., Choudhury D., Halder B., Paul P., Uddin A., Chakraborty S. A review on coronary artery disease, its risk factors, and therapeutics. J. Cell Physiol. 2019;234:16812–16823. doi: 10.1002/jcp.28350. - DOI - PubMed

[8] Malakar A.K., Choudhury D., Halder B., Paul P., Uddin A., Chakraborty S. A review on coronary artery disease, its risk factors, and therapeutics. J. Cell Physiol. 2019;234:16812–16823. doi: 10.1002/jcp.28350. - DOI - PubMed

[9] Katta N., Loethen T., Lavie C.J., Alpert M.A. Obesity and Coronary Heart Disease: Epidemiology, Pathology, and Coronary Artery Imaging. Curr. Probl. Cardiol. 2021;46:100655–100681. doi: 10.1016/j.cpcardiol.2020.100655. - DOI - PubMed

[10] Katta N., Loethen T., Lavie C.J., Alpert M.A. Obesity and Coronary Heart Disease: Epidemiology, Pathology, and Coronary Artery Imaging. Curr. Probl. Cardiol. 2021;46:100655–100681. doi: 10.1016/j.cpcardiol.2020.100655. - DOI - PubMed

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Long-Term Exposure of Nitrogen Oxides Air Pollution (NO₂) Impact for Coronary Artery Lesion Progression-Pilot Study

Affiliations

Long-Term Exposure of Nitrogen Oxides Air Pollution (NO₂) Impact for Coronary Artery Lesion Progression-Pilot Study

Authors

Affiliations

Abstract

Conflict of interest statement

Figures

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References

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Abstract

Conflict of interest statement

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References

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