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Review
. 2023 Sep 15;31(6):877-885.
doi: 10.32604/or.2023.029494. eCollection 2023.

Progress in research on tumor microenvironment-based spatial omics technologies

Fangmei Xie  1 , Naite Xi  1 , Zeping Han  1 , Wenfeng Luo  1 , Jian Shen  1 , Jinggeng Luo  2 , Xingkui Tang  2 , Ting Pang  1 , Yubing Lv  1 , Jiabing Liang  1 , Liyin Liao  1 , Haoyu Zhang  1 , Yong Jiang  1 , Yuguang Li  3 , Jinhua He  1
Affiliations
Review

Progress in research on tumor microenvironment-based spatial omics technologies

Fangmei Xie et al. Oncol Res. .

Abstract

Spatial omics technology integrates the concept of space into omics research and retains the spatial information of tissues or organs while obtaining molecular information. It is characterized by the ability to visualize changes in molecular information and yields intuitive and vivid visual results. Spatial omics technologies include spatial transcriptomics, spatial proteomics, spatial metabolomics, and other technologies, the most widely used of which are spatial transcriptomics and spatial proteomics. The tumor microenvironment refers to the surrounding microenvironment in which tumor cells exist, including the surrounding blood vessels, immune cells, fibroblasts, bone marrow-derived inflammatory cells, various signaling molecules, and extracellular matrix. A key issue in modern tumor biology is the application of spatial omics to the study of the tumor microenvironment, which can reveal problems that conventional research techniques cannot, potentially leading to the development of novel therapeutic agents for cancer. This paper summarizes the progress of research on spatial transcriptomics and spatial proteomics technologies for characterizing the tumor immune microenvironment.

Keywords: Spatial omics; Spatial proteomics; Spatial transcriptomics; Tumor microenvironment.

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Conflict of interest statement

The authors declare that they have no conflicts of interest to report regarding the present study.

Figures

Figure 1
Figure 1. The basic technical principles and classification of spatial transcriptomic techniques.
See this image and copyright information in PMC

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