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. 2024 Mar;397(3):1791-1801.
doi: 10.1007/s00210-023-02730-z. Epub 2023 Sep 23.

Caffeic acid phenethyl ester attenuates indomethacin-induced gastric ulcer in rats

Thikryat Neamatallah  1
Affiliations

Caffeic acid phenethyl ester attenuates indomethacin-induced gastric ulcer in rats

Thikryat Neamatallah. Naunyn Schmiedebergs Arch Pharmacol. 2024 Mar.

Abstract

Gastric ulcer is one of the most frequent gastrointestinal ailments worldwide. Indomethacin, one of the most potent NSAIDs, suffers undesirable ulcerogenic activity. Caffeic acid phenethyl ester (CAPE) has known health benefits. The current study examined the potential of CAPE to combat indomethacin-induced gastric ulcers in rats. Animals were randomized into 5 groups: control, Indomethacin (50 mg/kg) mg/kg), Indomethacin + CAPE (5 mg/kg/day), Indomethacin + CAPE (10 mg/kg), and Indomethacin + Omeprazole (30 mg/kg). CAPE prevented the rise in ulcer index, attenuated histopathological changes and preserved gastric mucin concentration. CAPE efficiently significantly prevented accumulation of malondialdehude (MDA) and prevented exhaustion of the enzymatic activities of catalase (CAT) and superoxide dismutase (SOD). Further, CAPE prevented the rise in the expression of tumor necrosis factor-α (TNF-α), cyclo-oxygenase-2 (COX-2) and nuclear factor kapp-B (NFκB). This was associated with down-regulation of Bax and up-regulation of Bcl-2 mRNA. Finally, CAPE prevented induced indomethacin-induced decrease in heat shock protein 70 (HSP70) in gastric tissues. In conclusion, CAPE possesses the ability to prevent indomethacin-induced gastric ulcer in rats. This involves, at least partially, antioxidation, anti-inflammation, anti-apoptosis and enhancement of HSP70 expression.

Keywords: Anti-inflammation; Antioxidantion; Caffeic acid phenethyl ester; Gastric ulcers; Heat shock protein 70; Indomethacin.

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