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Review
. 2023 Sep 4:10:1197745.
doi: 10.3389/fnut.2023.1197745. eCollection 2023.

Association between wine consumption and cancer: a systematic review and meta-analysis

Maribel Lucerón-Lucas-Torres  1 , Iván Cavero-Redondo  1   2 , Vicente Martínez-Vizcaíno  1   2 , Bruno Bizzozero-Peroni  1   3 , Carlos Pascual-Morena  1 , Celia Álvarez-Bueno  1   4
Affiliations
Review

Association between wine consumption and cancer: a systematic review and meta-analysis

Maribel Lucerón-Lucas-Torres et al. Front Nutr. .

Abstract

Background: Alcohol consumption is related to the risk of developing different types of cancer. However, unlike other alcoholic beverages, moderate wine drinking has demonstrated a protective effect on the risk of developing several types of cancer.

Objective: To analyze the association between wine consumption and the risk of developing cancer.

Methods: We searched the MEDLINE (through PubMed), Scopus, Cochrane, and Web of Science databases to conduct this systematic review and meta-analysis. Pooled relative risks (RRs) were calculated using the DerSimonian and Laird methods. I2 was used to evaluate inconsistency, the τ2 test was used to assess heterogeneity, and The Newcastle-Ottawa Quality Assessment Scale were applied to evaluate the risk of bias. This study was previously registered in PROSPERO, with the registration number CRD42022315864.

Results: Seventy-three studies were included in the systematic review, and 26 were included in the meta-analysis. The pooled RR for the effect of wine consumption on the risk of gynecological cancers was 1.03 (95% CI: 0.99, 1.08), that for colorectal cancer was 0.92 (95% CI: 0.82, 1.03), and that for renal cancer was 0.92 (95% CI: 0.81, 1.04). In general, the heterogeneity was substantial.

Conclusion: The study findings reveal no association between wine consumption and the risk of developing any type of cancer. Moreover, wine drinking demonstrated a protective trend regarding the risk of developing pancreatic, skin, lung, and brain cancer as well as cancer in general.

Systematic review registration: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42022315864, identifier CRD42022315864 (PROSPERO).

Keywords: adult people; alcohol consumption; cancer; systematic review and meta-analysis; wine.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
PRISMA 2020 flow diagram for new systematic reviews including database searches.
Figure 2
Figure 2
Meta-analysis of the association between wine consumption and gynecological cancers. Horizontal lines represent the 95% confidence intervals of the study, and the black boxes represent the effect size of each study.
Figure 3
Figure 3
Funnel plot of the different cancers.
Figure 4
Figure 4
Meta-analysis of the association between wine consumption and colorectal cancer. Horizontal lines represent the 95% confidence intervals of the study, and the black boxes represent the effect size of each study.
Figure 5
Figure 5
Meta-analysis of the association between wine consumption and renal cancer. Horizontal lines represent the 95% confidence intervals of the study, and the black boxes represent the effect size of each study.
Figure 6
Figure 6
Meta-analysis of the association between wine consumption and pancreatic, skin, lung, brain and general cancer. Horizontal lines represent the 95% confidence intervals of the study, and the black boxes represent the effect size of each study.
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