Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 Sep 18;21(1):239.
doi: 10.1186/s12964-023-01255-5.

Dysregulation of inflammasome activation in glioma

JeongMin Sim #  1   2 , JeongMan Park #  1   2 , Jong-Seok Moon #  3 , Jaejoon Lim #  4   5
Affiliations
Review

Dysregulation of inflammasome activation in glioma

JeongMin Sim et al. Cell Commun Signal. .

Abstract

Gliomas are the most common brain tumors characterized by complicated heterogeneity. The genetic, molecular, and histological pathology of gliomas is characterized by high neuro-inflammation. The inflammatory microenvironment in the central nervous system (CNS) has been closely linked with inflammasomes that control the inflammatory response and coordinate innate host defenses. Dysregulation of the inflammasome causes an abnormal inflammatory response, leading to carcinogenesis in glioma. Because of the clinical importance of the various physiological properties of the inflammasome in glioma, the inflammasome has been suggested as a promising treatment target for glioma management. Here, we summarize the current knowledge on the contribution of the inflammasomes in glioma and therapeutic insights. Video Abstract.

Keywords: Glioma; Inflammasome; Neuroinflammation; Therapeutic strategy.

PubMed Disclaimer

Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Devastating roles of neuroinflammation in glioma. The inflammatory response in glioma can induce BBB dysregulation (green section). Aggressive neuroinflammation of the glioma immune microenvironment exhibits intricate heterogeneity (purple section). In view of metabolism dysregulation, neuroinflammation convert metabolic balance of glioma cells (blue section). Glioma with chronic inflammation exhibits significant resistance to chemo/immuno-therapy (gray section)
Fig. 2
Fig. 2
Schematic representation showing that general structure, assembly and activating pathway (canonical and non-canonical) for inflammasome in glioma. Potential therapeutic candidate agents for inflammasome targets were suggested in red marker
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Ostrom QT, Bauchet L, Davis FG, et al. The epidemiology of glioma in adults: a "state of the science" review. Neuro Oncol. 2014;16(7):896–913. doi: 10.1093/neuonc/nou087. - DOI - PMC - PubMed
    1. Weller M, Wick W, Aldape K, et al. Glioma. Nature reviews Disease primers. Jul 16 2015;1:15017. 10.1038/nrdp.2015.17 - PubMed
    1. Swartz MA, Iida N, Roberts EW, et al. Tumor microenvironment complexity: emerging roles in cancer therapy. Can Res. 2012;72(10):2473–2480. doi: 10.1158/0008-5472.can-12-0122. - DOI - PMC - PubMed
    1. Balkwill FR, Capasso M, Hagemann T. The tumor microenvironment at a glance. J Cell Sci. 2012;125(Pt 23):5591–5596. doi: 10.1242/jcs.116392. - DOI - PubMed
    1. Litak J, Mazurek M, Grochowski C, Kamieniak P, Roliński J. PD-L1/PD-1 Axis in Glioblastoma Multiforme. International journal of molecular sciences.2019;20(21):10.3390/ijms20215347 - PMC - PubMed