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Clinical Trial
. 2023 Oct;8(5):101636.
doi: 10.1016/j.esmoop.2023.101636. Epub 2023 Sep 12.

Ramucirumab plus FOLFIRI as second-line treatment for patients with RAS wild-type metastatic colorectal cancer previously treated with anti-EGFR antibody: JACCRO CC-16

H Yasui  1 , Y Okita  2 , M Nakamura  3 , T Sagawa  4 , T Watanabe  5 , K Kataoka  6 , D Manaka  7 , K Shiraishi  8 , N Akazawa  9 , T Okuno  10 , T Shimura  11 , M Shiozawa  12 , Y Sunakawa  13 , H Ota  14 , M Kotaka  15 , H Okuyama  2 , M Takeuchi  16 , W Ichikawa  17 , M Fujii  18 , A Tsuji  19
Affiliations
Clinical Trial

Ramucirumab plus FOLFIRI as second-line treatment for patients with RAS wild-type metastatic colorectal cancer previously treated with anti-EGFR antibody: JACCRO CC-16

H Yasui et al. ESMO Open. 2023 Oct.

Abstract

Background: Chemotherapy in combination with anti-epidermal growth factor receptor (EGFR) antibody is considered a first-line treatment regimen for RAS wild-type and left-sided metastatic colorectal cancer (mCRC), whereas second-line treatment regimens have not yet been established. Few studies have prospectively evaluated second-line treatment with anti-vascular endothelial growth factor antibody after first-line anti-EGFR antibody therapy for RAS wild-type mCRC.

Patients and methods: This non-randomized phase II trial investigated the clinical outcomes of second-line ramucirumab (RAM) plus fluorouracil, levofolinate, and irinotecan (FOLFIRI) after first-line anti-EGFR antibody in combination with doublet or triplet regimen in patients with RAS wild-type mCRC. The primary endpoint was the 6-month progression-free survival (PFS) rate. The secondary endpoints were PFS, overall survival (OS), objective response rate (ORR), rate of early tumor shrinkage (ETS), and safety. We hypothesized a threshold 6-month PFS rate of 30% and an expected 6-month PFS rate of 45%. Treatment was considered effective if the lower limit of the 90% confidence interval (CI) of the 6-month PFS rate was >0.30.

Results: Ninety-two patients were enrolled in the study. The primary tumor was located on the left side in 86 (95.6%) patients. Twenty (22.0%) patients had received triplet plus cetuximab as previous therapy. Six-month PFS rate was 58.2% (90% CI 49.3% to 66.2%) with a median PFS of 7.0 months (95% CI 5.7-7.6 months). Median OS was 23.6 months (95% CI 16.5-26.3 months). The ORR and ETS rate were 10.7% and 16.9%, respectively, in 83 patients with measurable lesions. The 6-month PFS rate was comparable between patients previously treated with doublet and triplet regimens; however, median PFS was longer for the doublet regimen (7.4 versus 6.4 months, P = 0.036).

Conclusions: Our study demonstrated prospectively that RAM plus FOLFIRI is an effective second-line treatment after anti-EGFR antibody-containing first-line therapy in RAS wild-type and left-sided mCRC. Furthermore, the results were similar for patients who were previously treated with triplet regimen.

Keywords: RAS wild-type; chemotherapy; colorectal cancer; ramucirumab.

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Figures

Figure 1
Figure 1
Progression-free survival (PFS). CI, confidence interval.
Figure 2
Figure 2
Percentage change from baseline in the sum of diameters of measurable tumors at the first. ETS, early tumor shrinkage.
Figure 3
Figure 3
Progression-free survival (PFS) by previous treatment (doublet or triplet). CI, confidence interval.
See this image and copyright information in PMC

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