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. 2023 Aug 25;40(4):625-631.
doi: 10.7507/1001-5515.202211011.

[Research progress on vascularization of organoids]

[Article in Chinese]
Junyi Shen  1 , Zhi Ouyang  1 , Jian Zhong  1 , Yicen Long  1 , Yujia Sun  1 , Ye Zeng  1
Affiliations

[Research progress on vascularization of organoids]

[Article in Chinese]
Junyi Shen et al. Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. .

Abstract
in English, Chinese

Organoids are three-dimensional structures formed by self-organizing growth of cells in vitro, which own many structures and functions similar with those of corresponding in vivo organs. Although the organoid culture technologies are rapidly developed and the original cells are abundant, the organoid cultured by current technologies are rather different with the real organs, which limits their application. The major challenges of organoid cultures are the immature tissue structure and restricted growth, both of which are caused by poor functional vasculature. Therefore, how to develop the vascularization of organoids has become an urgent problem. We presently reviewed the progresses on the original cells of organoids and the current methods to develop organoids vascularization, which provide clues to solve the above-mentioned problems.

类器官是在体外通过细胞自组织生长而形成的三维结构，它具有许多与相应在体器官相类似的结构和功能。类器官培养技术发展迅速，起源细胞类型丰富，但是现有技术培养的类器官和真正的器官还具有很大差别，限制了类器官的广泛应用。限制类器官的主要问题有组织结构不成熟和生长受限，而缺少功能性血管系统则是根本原因，如何在类器官模型中发展血管系统已成为亟待解决的问题。本文主要综述了类器官的起源细胞以及类器官血管化的研究进展，为后续研究提供了线索。.

Keywords: Blood vessels; Coculture; Endothelial cells; Organoids; Stem cells.

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Conflict of interest statement

利益冲突声明：本文全体作者均声明不存在利益冲突。

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Grants and funding

国家自然科学基金（12272246）；四川省科技厅项目（2023YFS0075）

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