Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 Aug 30;14(1):230.
doi: 10.1186/s13287-023-03454-w.

Effects of Dopamine on stem cells and its potential roles in the treatment of inflammatory disorders: a narrative review

Guan-Qiao Liu #  1   2 , Zi-Xian Liu #  1   2 , Ze-Xin Lin  1   2 , Peng Chen  1   2 , Yu-Chi Yan  1   2 , Qing-Rong Lin  1 , Yan-Jun Hu  1 , Nan Jiang  3   4 , Bin Yu  5   6
Affiliations
Review

Effects of Dopamine on stem cells and its potential roles in the treatment of inflammatory disorders: a narrative review

Guan-Qiao Liu et al. Stem Cell Res Ther. .

Abstract

Inflammation is the host's protective response against harmful external stimulation that helps tissue repair and remodeling. However, excessive inflammation seriously threatens the patient's life. Due to anti-inflammatory effects, corticosteroids, immunosuppressants, and monoclonal antibodies are used to treat various inflammatory diseases, but drug resistance, non-responsiveness, and severe side effect limit their development and application. Therefore, developing other alternative therapies has become essential in anti-inflammatory therapy. In recent years, the in-depth study of stem cells has made them a promising alternative drug for the treatment of inflammatory diseases, and the function of stem cells is regulated by a variety of signals, of which dopamine signaling is one of the main influencing factors. In this review, we review the effects of dopamine on various adult stem cells (neural stem cells, mesenchymal stromal cells, hematopoietic stem cells, and cancer stem cells) and their signaling pathways, as well as the application of some critical dopamine receptor agonists/antagonists. Besides, we also review the role of various adult stem cells in inflammatory diseases and discuss the potential anti-inflammation function of dopamine receptors, which provides a new therapeutic target for regenerative medicine in inflammatory diseases.

Keywords: Cancer stem cell; Dopamine; Hematopoietic stem cell; Inflammatory disorders; Mesenchymal stromal cell; Neuron stem cell.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1
Fig. 1
Mechanism of how dopamine and its receptor regulate mesenchymal stromal cells and neuron, hematopoietic, cancer stem cells (This image is depicted by our team)
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Warren N, O'Gorman C, Lehn A, Siskind D. Dopamine dysregulation syndrome in Parkinson's disease: a systematic review of published cases. J Neurol Neurosurg Psychiatry. 2017;88(12):1060–1064. - PubMed
    1. Goldberg LI. Cardiovascular and renal actions of dopamine: potential clinical applications. Pharmacol Rev. 1972;24(1):1–29. - PubMed
    1. Marinosci GZ, De Robertis E, De Benedictis G, Piazza O. Dopamine use in intensive care: are we ready to turn it down? Transl Med UniSa. 2012;4:90–94. - PMC - PubMed
    1. Murphy MB. Dopamine: a role in the pathogenesis and treatment of hypertension. J Hum Hypertens. 2000;14(Suppl 1):S47–50. - PubMed
    1. Feng Y, Lu Y. Immunomodulatory effects of dopamine in inflammatory diseases. Front Immunol. 2021;12:663102. - PMC - PubMed

Publication types

LinkOut - more resources