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Review
. 2023 May 31:4:100060.
doi: 10.1016/j.crimmu.2023.100060. eCollection 2023.

Semaphorins in immune cell function, inflammatory and infectious diseases

Rony Thomas  1 , Xi Yang  1
Affiliations
Review

Semaphorins in immune cell function, inflammatory and infectious diseases

Rony Thomas et al. Curr Res Immunol. .

Abstract

The Semaphorin family is a group of proteins studied broadly for their functions in nervous systems. They consist of eight subfamilies ubiquitously expressed in vertebrates, invertebrates, and viruses and exist in membrane-bound or secreted forms. Emerging evidence indicates the relevance of semaphorins outside the nervous system, including angiogenesis, cardiogenesis, osteoclastogenesis, tumour progression, and, more recently, the immune system. This review provides a broad overview of current knowledge on the role of semaphorins in the immune system, particularly its involvement in inflammatory and infectious diseases, including chlamydial infections.

Keywords: Chlamydia; Immunity; Infection; Inflammation; Sema3E; Semaphorin.

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Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Image 1
Graphical abstract
Fig. 1
Fig. 1
Schematic model showing the mechanism by which Sema3E protects against chlamydial infection. Chlamydial lung infection induces the production of Sema3E. Sema3E binds to its receptor, plexinD1, expressed on DCs, thus upregulating co-stimulatory molecules, chemokine receptor (CCR7), and IL-12 cytokine production. Sema3E modulated DC migrate to the draining lymph nodes and promotes Th1/Th17 response and inhibits Th2 and Treg response. The modulated DC can also promote IgG2a antibody production. These responses result in the clearance of Chlamydia (Thomas et al., 2021), (Thomas et al., 2022).
See this image and copyright information in PMC

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