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Review
. 2023 Aug 18;11(8):2297.
doi: 10.3390/biomedicines11082297.

Brugada Syndrome: More than a Monogenic Channelopathy

Antonella Liantonio  1 , Matteo Bertini  2 , Antonietta Mele  1 , Cristina Balla  2 , Giorgia Dinoi  1 , Rita Selvatici  3 , Marco Mele  1   4 , Annamaria De Luca  1 , Francesca Gualandi  3 , Paola Imbrici  1
Affiliations
Review

Brugada Syndrome: More than a Monogenic Channelopathy

Antonella Liantonio et al. Biomedicines. .

Abstract

Brugada syndrome (BrS) is an inherited cardiac channelopathy first diagnosed in 1992 but still considered a challenging disease in terms of diagnosis, arrhythmia risk prediction, pathophysiology and management. Despite about 20% of individuals carrying pathogenic variants in the SCN5A gene, the identification of a polygenic origin for BrS and the potential role of common genetic variants provide the basis for applying polygenic risk scores for individual risk prediction. The pathophysiological mechanisms are still unclear, and the initial thinking of this syndrome as a primary electrical disease is evolving towards a partly structural disease. This review focuses on the main scientific advancements in the identification of biomarkers for diagnosis, risk stratification, pathophysiology and therapy of BrS. A comprehensive model that integrates clinical and genetic factors, comorbidities, age and gender, and perhaps environmental influences may provide the opportunity to enhance patients' quality of life and improve the therapeutic approach.

Keywords: Brugada syndrome; Nav1.5; SCN5A; arrhythmia; cardiac channelopathy.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Management of BrS patients.
Figure 2
Figure 2
Functional characterization of the Nav1.5 P1310L variant in S4 DIII identified in a family affected by BrS described in [29]. The blue star indicates the location of the P1310L variant on channel structure.
See this image and copyright information in PMC

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References

    1. Brugada P., Brugada J. Right bundle branch block, persistent ST segment elevation and sudden cardiac death: A distinct clinical and electrocardiographic syndrome. A multicenter report. J. Am. Coll. Cardiol. 1992;20:1391–1396. doi: 10.1016/0735-1097(92)90253-J. - DOI - PubMed
    1. Garcia-Elias A., Benito B. Ion channel disorders and sudden cardiac death. Int. J. Mol. Sci. 2018;19:692. doi: 10.3390/ijms19030692. - DOI - PMC - PubMed
    1. Priori S.G., Blomström-Lundqvist C., Mazzanti A., Blom N., Borggrefe M., Camm J., Elliott P.M., Fitzsimons D., Hatala R., Hindricks G., et al. 2015 ESC Guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: The Task Force for the Management of Patients with Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death of the European Society of Cardiology (ESC). Endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC) Eur. Heart J. 2015;36:2793–2867. doi: 10.1093/eurheartj/ehv316. - DOI - PubMed
    1. Offerhaus J.A., Bezzina C.R., Wilde A.A.M. Epidemiology of inherited arrhythmias. Nat. Rev. Cardiol. 2020;17:205–215. doi: 10.1038/s41569-019-0266-2. - DOI - PubMed
    1. Postema P.G., Wilde A.A.M. Aging in Brugada Syndrome: What about risks? JACC Clin. Electrophysiol. 2017;3:68–70. doi: 10.1016/j.jacep.2016.05.014. - DOI - PubMed

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