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. 2023 Aug 2;11(8):2174.
doi: 10.3390/biomedicines11082174.

The Association between Serum Adiponectin Levels and Endothelial Function in Non-Dialysis-Dependent Chronic Kidney Disease Patients

Ming-Chun Chen  1   2 , Chung-Jen Lee  3 , Yu-Li Lin  2   4 , Chih-Hsien Wang  2   4 , Bang-Gee Hsu  2   4
Affiliations

The Association between Serum Adiponectin Levels and Endothelial Function in Non-Dialysis-Dependent Chronic Kidney Disease Patients

Ming-Chun Chen et al. Biomedicines. .

Abstract

Adiponectin is the richest human circulating adipokine with anti-inflammatory, antioxidant, and insulin-sensitizing effects. We evaluated the association between serum adiponectin levels and endothelial function in chronic kidney disease (CKD) patients, obtaining fasting blood samples from 130 non-dialysis CKD subjects. We measured the endothelial function-represented by the vascular reactivity index (VRI)-via non-invasive digital thermal monitoring, and serum adiponectin concentrations by enzyme immunoassay kits. A total of 22 (16.9%), 39 (30.0%), and 69 (53.1%) patients had poor (VRI < 1.0), intermediate (1.0 ≤ VRI < 2.0), and good (VRI ≥ 2.0) vascular reactivity. Elevated serum blood urea nitrogen (BUN) level was negatively correlated with VRI values, but serum adiponectin and estimated glomerular filtration rate were positively associated with VRI values by univariate linear regression analysis. After applying multivariate stepwise linear regression analysis adjustment, the significantly positive association of adiponectin (p < 0.001), and the significantly negative association of log-BUN (p = 0.021) with VRI values in CKD subjects remained. In an animal study using in vitro blood-vessel myography, treatment with adiponectin enhancing acetylcholine-mediated vasorelaxation in 5/6 nephrectomy CKD mice. Our study results indicated that adiponectin concentration was positively associated with VRI values and modulated endothelial function in non-dialysis CKD patients.

Keywords: adiponectin; blood-vessel myography; chronic kidney disease; digital thermal monitoring test; endothelial function; vascular reactivity index.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Relationships between vascular reactive index (VRI) and (a) log-BUN level (ng/mL), (b) eGFR (mL/min), or (c) adiponectin level (ng/mL) among 130 chronic kidney disease patients.
Figure 1
Figure 1
Relationships between vascular reactive index (VRI) and (a) log-BUN level (ng/mL), (b) eGFR (mL/min), or (c) adiponectin level (ng/mL) among 130 chronic kidney disease patients.
Figure 2
Figure 2
Serum levels of adiponectin to CKD staging.
Figure 3
Figure 3
Adiponectin treatment ameliorates the CKD-induced hyporeactivity to vasorelaxation in the mouse aorta. * p < 0.05 for the CKD + adiponectin group compared with the CKD group. # p < 0.05 for the adiponectin group compared with control group. + p < 0.05 for the CKD group compared with the control group.
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