Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 Aug 17;13(8):952.
doi: 10.3390/metabo13080952.

Bacterial Metabolites and Inflammatory Skin Diseases

Victoria Jiminez  1 , Nabiha Yusuf  2
Affiliations
Review

Bacterial Metabolites and Inflammatory Skin Diseases

Victoria Jiminez et al. Metabolites. .

Abstract

The microbiome and gut-skin axis are popular areas of interest in recent years concerning inflammatory skin diseases. While many bacterial species have been associated with commensalism of both the skin and gastrointestinal tract in certain disease states, less is known about specific bacterial metabolites that regulate host pathways and contribute to inflammation. Some of these metabolites include short chain fatty acids, amine, and tryptophan derivatives, and more that when dysregulated, have deleterious effects on cutaneous disease burden. This review aims to summarize the knowledge of wealth surrounding bacterial metabolites of the skin and gut and their role in immune homeostasis in inflammatory skin diseases such as atopic dermatitis, psoriasis, and hidradenitis suppurativa.

Keywords: atopic dermatitis; bacterial metabolites; gut-skin axis; hidradenitis suppurativa; immune regulation; inflammatory skin disease; microbiome; psoriasis.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Roles of short chain fatty acids on immune function and epidermal homeostasis (Created with Biorender 2023 version).
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Stec A., Sikora M., Maciejewska M., Paralusz-Stec K., Michalska M., Sikorska E., Rudnicka L. Bacterial Metabolites: A Link between Gut Microbiota and Dermatological Diseases. Int. J. Mol. Sci. 2023;24:3494. doi: 10.3390/ijms24043494. - DOI - PMC - PubMed
    1. Brown J., Robusto B., Morel L. Intestinal Dysbiosis and Tryptophan Metabolism in Autoimmunity. Front. Immunol. 2020;11:1741. doi: 10.3389/fimmu.2020.01741. - DOI - PMC - PubMed
    1. Yao Y., Cai X., Fei W., Ye Y., Zhao M., Zheng C. The Role of Short-Chain Fatty Acids in Immunity, Inflammation and Metabolism. Crit. Rev. Food Sci. Nutr. 2022;62:1–12. doi: 10.1080/10408398.2020.1854675. - DOI - PubMed
    1. Kałużna-Czaplińska J., Gątarek P. Trimethylamine N-Oxide (TMAO) in Human Health. EXCLI J. 2021;20:301–319. doi: 10.17179/excli2020-3239. - DOI - PMC - PubMed
    1. De Pessemier B., Grine L., Debaere M., Maes A., Paetzold B., Callewaert C. Gut–Skin Axis: Current Knowledge of the Interrelationship between Microbial Dysbiosis and Skin Conditions. Microorganisms. 2021;9:353. doi: 10.3390/microorganisms9020353. - DOI - PMC - PubMed

Grants and funding

This research received no external funding.

LinkOut - more resources