Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 Aug 4;13(8):1232.
doi: 10.3390/jpm13081232.

COVID-19 Vaccines and Assisted Reproductive Techniques: A Systematic Review

Elena Satorres-Pérez  1 , Alicia Martínez-Varea  1 , José Morales-Roselló  1
Affiliations
Review

COVID-19 Vaccines and Assisted Reproductive Techniques: A Systematic Review

Elena Satorres-Pérez et al. J Pers Med. .

Abstract

Objective: To review the current knowledge concerning COVID-19 vaccination and assisted reproductive techniques (ART). Methods: A systematic review in Pubmed-Medline, the Cochrane Database, the Web of Science, and the National Guideline was performed. Studies were selected if they were primary studies, included vaccinated (case) and unvaccinated (control) patients, and described fertility treatment response. Results: A total of 24 studies were selected. Outcomes related to the association between COVID-19 vaccination and ART were collected. The vast majority of studies found no statistical differences concerning oocyte stimulation response, embryo quality, implantation rates, or pregnancy outcome (clinical or biochemical pregnancy rates and losses) when comparing cases and controls. Similarly, no differences were found when comparing different types of vaccines or distinct ART (artificial insemination, in vitro fertilization, and embryo transfer of frozen embryos). Conclusions: Patients receiving ART and health care professionals should be encouraged to complete and recommend COVID-19 vaccination, as the available evidence regarding assisted reproductive outcomes is reassuring.

Keywords: COVID-19; SARS-CoV-2; assisted reproductive techniques (ART); embryo; fertility; in vitro fertilization (IVF); pregnancy; reproduction; vaccine.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Flow diagram representing the article selection process.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Holmes K.V. SARS coronavirus: A new challenge for prevention and therapy. J. Clin. Investig. 2003;111:1605–1609. doi: 10.1172/JCI18819. - DOI - PMC - PubMed
    1. Wan Y., Shang J., Graham R., Baric R.S., Li F. Receptor recognition by the novel coronavirus from Wuhan: An analysis based on decade-long structural studies of SARS coronavirus. J. Virol. 2020;94:e00127–e220. - PMC - PubMed
    1. Jean A., Quach C., Yung A., Semret M. Severity and outcome associated with human coronavirus OC43 infections among children. Pediatr. Infect. Dis. J. 2013;32:325–329. doi: 10.1097/INF.0b013e3182812787. - DOI - PubMed
    1. SeyedAlinaghi S., Karimi A., Barzegary A., Mojdeganlou H., Vahedi F., Mirghaderi S.P., Shobeiri P., Ramezani M., Yousefi Konjdar P., Mirzapour P., et al. COVID-19 mortality in patients with immunodeficiency and its predictors: A systematic review. Eur. J. Med. Res. 2022;27:195. doi: 10.1186/s40001-022-00824-7. - DOI - PMC - PubMed
    1. Bassetti M., Vena A., Roberto Giacobbe D. The Novel Chinese Coronavirus (2019-nCoV) Infections: Challenges for fighting the storm. Eur. J. Clin. Investig. 2020;50:e13209. doi: 10.1111/eci.13209. - DOI - PMC - PubMed

Grants and funding

This research received no external funding.

LinkOut - more resources